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Tbio
FANCA
Fanconi anemia group A protein

Protein Summary
Description
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding differen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389301
  • ENSP00000373952
  • ENSG00000187741
  • ENST00000389302
  • ENSP00000373953
  • ENST00000568369
  • ENSP00000456829

Symbol
  • FAA
  • FACA
  • FANCH
  • FA
  • FA1
  • FAA
  • FAH
  • FA-H
  • FACA
  • FANCH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.94
histone modification site profile
0.84
virus perturbation
0.83
transcription factor perturbation
0.74
disease
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 520.6   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 391   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 520.6   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 391   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (145)
FANCG
Tbio
Novelty:  0.00908902
p_int:  0.999999383
p_ni:  6.13e-7
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
FAAP20
Tbio
Novelty:  0.15112645
p_int:  0.999991349
p_ni:  0.00000865
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.970248727
p_ni:  0.029751268
p_wrong:  5e-9
Data Source:  BioPlex
C6orf118
Tdark
Novelty:  4.32054176
p_int:  0.947737952
p_ni:  0.052261885
p_wrong:  1.63e-7
Score:  0.19
Data Source:  BioPlex,STRINGDB
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.903454307
p_ni:  0.096541156
p_wrong:  0.000004537
Data Source:  BioPlex
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.808564224
p_ni:  0.191245845
p_wrong:  0.000189931
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.803075457
p_ni:  0.196916604
p_wrong:  0.00000794
Data Source:  BioPlex
IARS2
Tchem
Family:  Enzyme
Novelty:  0.00854621
p_int:  0.785770778
p_ni:  0.214139887
p_wrong:  0.000089334
Score:  0.181
Data Source:  BioPlex,STRINGDB
RMI1
Tbio
Novelty:  0.01222442
Score:  0.999
Data Source:  STRINGDB
FANCM
Tbio
Novelty:  0.01122278
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (59)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
5
21
1
2.5
99.9
suntan
1
8
8
98.4
5
2
0
1.7
98.3
homocysteine measurement
2
3
3
98.3
glomerular filtration rate
8
5
7
5.5
96.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
2.5
99.9
suntan
8
98.4
0
1.7
98.3
homocysteine measurement
3
98.3
glomerular filtration rate
7
5.5
96.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group A
VGNC:5765
454393
Mouse
MGI:1341823
14087
Rat
RGD:1311380
361435
Dog
FA complementation group A
VGNC:40716
608713
Horse
FA complementation group A
VGNC:17898
100052495
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group A
Mouse
Rat
Dog
FA complementation group A
Horse
FA complementation group A
Publication Statistics
PubMed Score 520.60
PubMed score by year
PubTator Score 276.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title