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Tdark
FAM98B
Protein FAM98B

Protein Summary
Description
Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). Promotes colorectal cancer cell malignancy (PubMed:28040436).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397609
  • ENSP00000380734
  • ENSG00000171262
  • ENST00000491535
  • ENSP00000453166
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.91
transcription factor perturbation
0.84
transcription factor binding site profile
0.77
tissue sample
0.63
histone modification site profile
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.73   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.73   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
DDX1
Tchem
Family:  Enzyme
Novelty:  0.01691884
p_int:  0.999643472
p_ni:  0.000356528
Score:  0.999
Data Source:  BioPlex,STRINGDB
RTRAF
Tbio
Novelty:  0.03996206
Score:  0.999
Data Source:  STRINGDB
C2orf49
Tbio
Novelty:  0.03911934
Score:  0.998
Data Source:  STRINGDB
RTCB
Tbio
Family:  Enzyme
Novelty:  0.01114311
Score:  0.998
Data Source:  STRINGDB
ZBTB8OS
Tbio
Family:  Enzyme
Novelty:  0.03929334
Score:  0.971
Data Source:  STRINGDB
RNPEP
Tchem
Family:  Enzyme
Novelty:  0.00381273
Score:  0.873
Data Source:  STRINGDB
PAFAH1B2
Tchem
Family:  Enzyme
Novelty:  0.07918203
Score:  0.859
Data Source:  STRINGDB
PPP1R8
Tbio
Family:  Enzyme
Novelty:  0.00138054
Score:  0.833
Data Source:  STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.68
Data Source:  STRINGDB
MORC3
Tbio
Novelty:  0.01216555
Score:  0.674
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the nucleus
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
8
6
4
1.1
97.5
4
2
2
1.1
93.2
autoimmune thyroid disease
1
1
0
1.1
78.5
1
1
0
1.9
76.9
educational attainment
1
2
2
63.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
4
1.1
97.5
2
1.1
93.2
autoimmune thyroid disease
0
1.1
78.5
0
1.9
76.9
educational attainment
2
63.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 98 member B
VGNC:11887
453315
Macaque
family with sequence similarity 98 member B
106999137
Mouse
MGI:1915465
68215
Rat
Dog
family with sequence similarity 98 member B
VGNC:40713
478254
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 98 member B
Macaque
family with sequence similarity 98 member B
Mouse
Rat
Dog
family with sequence similarity 98 member B
Publication Statistics
PubMed Score 1.73
PubMed score by year
PubTator Score 0.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title