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Tbio
FAM98A
Protein FAM98A

Protein Summary
Description
Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Promotes colorectal cancer cell malignancy (PubMed:28040436).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238823
  • ENSP00000238823
  • ENSG00000119812
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
disease perturbation
0.95
kinase perturbation
0.95
transcription factor perturbation
0.88
virus perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.48   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.48   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
FBXO31
Tbio
Novelty:  0.23426419
p_int:  0.999997563
p_wrong:  0.000002437
Score:  0.403
Data Source:  BioPlex,STRINGDB
DDX1
Tchem
Family:  Enzyme
Novelty:  0.01691884
p_int:  0.999994152
p_ni:  0.000005849
Score:  0.993
Data Source:  BioPlex,STRINGDB
N4BP2
Tbio
Novelty:  0.12823967
p_int:  0.99999336
p_ni:  0.00000664
Score:  0.332
Data Source:  BioPlex,STRINGDB
UXS1
Tbio
Family:  Enzyme
Novelty:  0.04671281
p_int:  0.999431363
p_ni:  0.000568637
Data Source:  BioPlex
BTBD1
Tbio
Novelty:  0.19772296
p_int:  0.997665181
p_ni:  0.002303372
p_wrong:  0.000031447
Score:  0.173
Data Source:  BioPlex,STRINGDB
SPATS2
Tdark
Novelty:  0.20594325
p_int:  0.997112377
p_ni:  0.002885927
p_wrong:  0.000001696
Score:  0.246
Data Source:  BioPlex,STRINGDB
SFPQ
Tbio
Novelty:  0.01207637
p_int:  0.988658485
p_ni:  0.011341515
Score:  0.259
Data Source:  BioPlex,STRINGDB
HERC2
Tbio
Family:  Enzyme
Novelty:  0.06552683
p_int:  0.976982692
p_ni:  0.023017308
Score:  0.191
Data Source:  BioPlex,STRINGDB
NEURL4
Tdark
Novelty:  0.20430708
p_int:  0.976962368
p_ni:  0.023037632
Data Source:  BioPlex
PINX1
Tbio
Family:  TF
Novelty:  0.01237398
p_int:  0.924463354
p_ni:  0.075536646
Score:  0.26
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroimaging measurement
1
1
1
51
brain volume measurement
2
1
2
28.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroimaging measurement
1
51
brain volume measurement
2
28.6
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 98 member A
VGNC:2936
459144
Macaque
family with sequence similarity 98 member A
707327
Mouse
MGI:1919972
72722
Rat
RGD:1305486
313873
Dog
family with sequence similarity 98 member A
VGNC:40712
475721
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 98 member A
Macaque
family with sequence similarity 98 member A
Mouse
Rat
Dog
family with sequence similarity 98 member A
Publication Statistics
PubMed Score 6.48
PubMed score by year
PubTator Score 1.82
PubTator score by year
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Related Publications
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PMID
Year
Title