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Tbio
FAM89B
Leucine repeat adapter protein 25

Protein Summary
Description
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316409
  • ENSP00000314829
  • ENSG00000176973
  • ENST00000449319
  • ENSP00000402439
  • ENST00000530349
  • ENSP00000431459

Symbol
  • Lrap25
  • MTVR
  • MTVR1
  • LRAP25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.6
histone modification site profile
0.58
cell line
0.54
transcription factor binding site profile
0.49
tissue
0.46


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.07   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.07   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0