Protein Summary
May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). The protein encoded by this gene plays an important role in the structural development and calcification of tooth enamel. Defects in this gene are a cause of amelogenesis imperfecta type 3 (AI3). [provided by RefSeq, Mar 2010]
- ENST00000388913
- ENSP00000373565
- ENSG00000180921
- ENST00000612192
- ENSP00000478790
- ENSG00000273889
- AI3
- AI3A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.99 | ||
transcription factor perturbation | 0.8 | ||
interacting protein | 0.78 | ||
tissue sample | 0.61 | ||
transcription factor binding site profile | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.66 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 35 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.66 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 35 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (78)
UNC45A
Novelty: 0.07503761
p_int: 0.999653573
p_ni: 0.000346427
Score: 0.354
Data Source: BioPlex,STRINGDB
TSGA10IP
Novelty: 20.75428866
p_int: 0.994740626
p_ni: 0.005259366
p_wrong: 9e-9
Data Source: BioPlex
TIAL1
Novelty: 0.01126806
p_int: 0.994651125
p_ni: 0.005348875
Score: 0.198
Data Source: BioPlex,STRINGDB
SKP2
Family: Enzyme
Novelty: 0.00182658
p_int: 0.993326047
p_ni: 0.006673953
Data Source: BioPlex
SEC23B
Novelty: 0.02307622
p_int: 0.988693868
p_ni: 0.011306127
p_wrong: 5e-9
Data Source: BioPlex
CSNK1D
Family: Kinase
Novelty: 0.00896935
p_int: 0.988626867
p_ni: 0.011373133
Score: 0.351
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
age at menarche | 1 | 1 | 1 | 24.5 | ||||||
age at menarche | 1 | 1 | 1 | 24.5 | ||||||
appendicular lean mass | 1 | 1 | 1 | 21.5 | ||||||
appendicular lean mass | 1 | 1 | 1 | 21.5 | ||||||
diastolic blood pressure | 1 | 1 | 1 | 15.8 | ||||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
age at menarche | 1 | 24.5 | |||||
age at menarche | 1 | 24.5 | |||||
appendicular lean mass | 1 | 21.5 | |||||
appendicular lean mass | 1 | 21.5 | |||||
diastolic blood pressure | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | family with sequence similarity 83 member H | VGNC:12007 | 464449 | |||||
Macaque | family with sequence similarity 83 member H | 698513 | ||||||
Mouse | MGI:2145900 | 105732 | ||||||
Rat | RGD:1305866 | 362937 | ||||||
Dog | family with sequence similarity 83 member H | VGNC:40705 | 482081 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | family with sequence similarity 83 member H | |||||
Macaque | family with sequence similarity 83 member H | |||||
Mouse | ||||||
Rat | ||||||
Dog | family with sequence similarity 83 member H | |||||
Publication Statistics
PubMed Score 50.66
PubMed score by year
PubTator Score 36.21
PubTator score by year
Related Publications
Text Mined References (24)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
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