Tbio FAM83H Protein FAM83H

Protein Summary

Description

May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). The protein encoded by this gene plays an important role in the structural development and calcification of tooth enamel. Defects in this gene are a cause of amelogenesis imperfecta type 3 (AI3). [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q6ZRV2
• A0JLS2
• Q8N4W0

Gene Name

• FAM83H

Ensembl ID

• ENST00000388913
• ENSP00000373565
• ENSG00000180921
• ENST00000612192
• ENSP00000478790
• ENSG00000273889

Symbol

• AI3
• AI3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
transcription factor perturbation	0.8
interacting protein	0.78
tissue sample	0.61
transcription factor binding site profile	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.03   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 35   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.03   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0