Protein Summary
Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.
- ENST00000619850
- ENSP00000481465
- ENSG00000101447
- C20orf129
- CHICA
- C20orf129
- dJ616B8.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor binding site profile | 0.77 | ||
transcription factor perturbation | 0.74 | ||
virus perturbation | 0.72 | ||
tissue sample | 0.68 | ||
kinase perturbation | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.47 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 75 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.47 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 75 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (120)
BACH1
Family: TF
Novelty: 0.04011328
p_int: 0.999998602
p_ni: 0.000001398
Score: 0.203
Data Source: BioPlex,STRINGDB
HMMR
Novelty: 0.0039196
p_int: 0.999995397
p_ni: 0.000004603
Score: 0.971
Data Source: BioPlex,STRINGDB
CSNK1A1
Family: Kinase
Novelty: 0.00636472
p_int: 0.998946167
p_ni: 0.001053833
Score: 0.566
Data Source: BioPlex,STRINGDB
CCDC40
Novelty: 0.06726469
p_int: 0.99880831
p_ni: 0.00119169
Score: 0.625
Data Source: BioPlex,STRINGDB
GMNN
Novelty: 0.00436572
p_int: 0.997443058
p_ni: 0.002556942
Score: 0.356
Data Source: BioPlex,STRINGDB
PSMC3
Family: Enzyme
Novelty: 0.04026019
p_int: 0.993376245
p_ni: 0.006623754
Data Source: BioPlex
TRAK2
Novelty: 0.04192075
p_int: 0.984132662
p_ni: 0.01585552
p_wrong: 0.000011818
Data Source: BioPlex
BBS7
Novelty: 0.03611111
p_int: 0.973404322
p_ni: 0.026594436
p_wrong: 0.000001242
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (3)
Components (2)
Processes (10)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 4 | 2 | 4 | 79.5 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 4 | 79.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:1919128 | 71878 | ||||||
Rat | RGD:1565583 | 311598 | ||||||
Dog | family with sequence similarity 83 member D | VGNC:40702 | 100683673 | |||||
Horse | family with sequence similarity 83 member D | VGNC:17890 | 100070299 | |||||
Cow | family with sequence similarity 83 member D | VGNC:28835 | 508561 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | family with sequence similarity 83 member D | |||||
Horse | family with sequence similarity 83 member D | |||||
Cow | family with sequence similarity 83 member D | |||||
Publication Statistics
PubMed Score 24.47
PubMed score by year
PubTator Score 36.67
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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