Tbio FAM83D Protein FAM83D

Protein Summary

Description

Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.

Uniprot Accession IDs

• Q9H4H8
• B4E1I7
• Q5THR2
• Q68EN1
• Q6P457
• Q7Z6H0
• Q96DF5
• Q96N89
• Q9BVM8

Gene Name

• FAM83D

Ensembl ID

• ENST00000619850
• ENSP00000481465
• ENSG00000101447

Symbol

• C20orf129
• CHICA
• C20orf129
• dJ616B8.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.77
transcription factor perturbation	0.74
virus perturbation	0.72
tissue sample	0.68
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.47   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.47   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (120)

Explore Interacting Targets

1 – 10 of 120

• See Interactions on String-DB

BACH1

Tbio

Family:  TF

Novelty:  0.04011328

p_int:  0.999998602

p_ni:  0.000001398

Score:  0.203

Data Source:  BioPlex,STRINGDB

HMMR

Tchem

Novelty:  0.0039196

p_int:  0.999995397

p_ni:  0.000004603

Score:  0.971

Data Source:  BioPlex,STRINGDB

CRYAA

Tchem

Novelty:  0.01914081

p_int:  0.999584273

p_ni:  0.000415727

Data Source:  BioPlex

ZAR1L

Tdark

Novelty:  0.08793345

p_int:  0.999576482

p_ni:  0.000423518

Data Source:  BioPlex

CSNK1A1

Tchem

Family:  Kinase

Novelty:  0.00636472

p_int:  0.998946167

p_ni:  0.001053833

Score:  0.566

Data Source:  BioPlex,STRINGDB

CCDC40

Tbio

Novelty:  0.06726469

p_int:  0.99880831

p_ni:  0.00119169

Score:  0.625

Data Source:  BioPlex,STRINGDB

GMNN

Tbio

Novelty:  0.00436572

p_int:  0.997443058

p_ni:  0.002556942

Score:  0.356

Data Source:  BioPlex,STRINGDB

PSMC3

Tbio

Family:  Enzyme

Novelty:  0.04026019

p_int:  0.993376245

p_ni:  0.006623754

Data Source:  BioPlex

TRAK2

Tbio

Novelty:  0.04192075

p_int:  0.984132662

p_ni:  0.01585552

p_wrong:  0.000011818

Data Source:  BioPlex

BBS7

Tbio

Novelty:  0.03611111

p_int:  0.973404322

p_ni:  0.026594436

p_wrong:  0.000001242

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (3)

Components (2)

Processes (10)

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1 – 3 of 3

GO Term	Evidence	Assigned by
microtubule binding	Inferred from Direct Assay (IDA)	UniProtKB
kinesin binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	4	2	4		79.5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	4		79.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Mitosis
Phosphoprotein
Proto-oncogene

GWAS Trait Find Similar Targets

No Header	No Header
sex hormone-binding globulin measurement

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	family with sequence similarity 83, member D	MGI:1919128	71878
Rat	family with sequence similarity 83, member D	RGD:1565583	311598
Dog	family with sequence similarity 83 member D	VGNC:40702	100683673
Horse	family with sequence similarity 83 member D	VGNC:17890	100070299
Cow	family with sequence similarity 83 member D	VGNC:28835	508561

Species	Name	OMA	EggNOG	Inparanoid
Mouse	family with sequence similarity 83, member D
Rat	family with sequence similarity 83, member D
Dog	family with sequence similarity 83 member D
Horse	family with sequence similarity 83 member D
Cow	family with sequence similarity 83 member D

Publication Statistics

PubMed Score 24.47

PubMed score by year

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PubTator Score 36.67

PubTator score by year

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Related Publications

Text Mined References (16)

GeneRif Annotations (8)

Items per page:

10

0 of 0

PMID	Year	Title