Tbio FAM83D Protein FAM83D

Protein Summary

Description

Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.

Uniprot Accession IDs

• Q9H4H8
• B4E1I7
• Q5THR2
• Q68EN1
• Q6P457
• Q7Z6H0
• Q96DF5
• Q96N89
• Q9BVM8

Gene Name

• FAM83D

Ensembl ID

• ENST00000619850
• ENSP00000481465
• ENSG00000101447

Symbol

• C20orf129
• CHICA
• C20orf129
• dJ616B8.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.77
transcription factor perturbation	0.74
virus perturbation	0.72
tissue sample	0.68
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.37   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.37   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0