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Tbio
FAM83D
Protein FAM83D

Protein Summary
Description
Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000619850
  • ENSP00000481465
  • ENSG00000101447

Symbol
  • C20orf129
  • CHICA
  • C20orf129
  • dJ616B8.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
transcription factor perturbation
0.74
virus perturbation
0.72
tissue sample
0.68
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.47   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.47   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (120)
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.999998602
p_ni:  0.000001398
Score:  0.203
Data Source:  BioPlex,STRINGDB
HMMR
Tchem
Novelty:  0.0039196
p_int:  0.999995397
p_ni:  0.000004603
Score:  0.971
Data Source:  BioPlex,STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.999584273
p_ni:  0.000415727
Data Source:  BioPlex
ZAR1L
Tdark
Novelty:  0.08793345
p_int:  0.999576482
p_ni:  0.000423518
Data Source:  BioPlex
CSNK1A1
Tchem
Family:  Kinase
Novelty:  0.00636472
p_int:  0.998946167
p_ni:  0.001053833
Score:  0.566
Data Source:  BioPlex,STRINGDB
CCDC40
Tbio
Novelty:  0.06726469
p_int:  0.99880831
p_ni:  0.00119169
Score:  0.625
Data Source:  BioPlex,STRINGDB
GMNN
Tbio
Novelty:  0.00436572
p_int:  0.997443058
p_ni:  0.002556942
Score:  0.356
Data Source:  BioPlex,STRINGDB
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.993376245
p_ni:  0.006623754
Data Source:  BioPlex
TRAK2
Tbio
Novelty:  0.04192075
p_int:  0.984132662
p_ni:  0.01585552
p_wrong:  0.000011818
Data Source:  BioPlex
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.973404322
p_ni:  0.026594436
p_wrong:  0.000001242
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
79.5
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919128
71878
Rat
RGD:1565583
311598
Dog
family with sequence similarity 83 member D
VGNC:40702
100683673
Horse
family with sequence similarity 83 member D
VGNC:17890
100070299
Cow
family with sequence similarity 83 member D
VGNC:28835
508561
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
family with sequence similarity 83 member D
Horse
family with sequence similarity 83 member D
Cow
family with sequence similarity 83 member D
Publication Statistics
PubMed Score 24.47
PubMed score by year
PubTator Score 36.67
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title