You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FAM83D
Protein FAM83D

Protein Summary
Description
Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000619850
  • ENSP00000481465
  • ENSG00000101447

Symbol
  • C20orf129
  • CHICA
  • C20orf129
  • dJ616B8.3
Illumination Graph
0.8 0.6 0.4 0.2
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
transcription factor perturbation
0.74
virus perturbation
0.72
tissue sample
0.68
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.37   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.37   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (350 Tissues)
none
JensenLab TISSUES
JensenLab TISSUESGTEx - FemaleGTEx - MaleHPA RNAHPM ProteinExpression Typemulticellular organismbody propergenitourinary systemglandreproductive systemfemale reproductive systemviscusinternal female genitaliarenal systemembryonic structurelungrespiratory systemkidneyuterusplacentalate embryotracheaendocrine glanddigestive systemhematopoietic systembloodinternal male genitaliamale reproductive systemhematopoietic cellesophagusdigestive tractintestineintegumenttestiscolongonadlarge intestineimmune systemskeletal systemlymphoid tissueleukocytelymphocyteovaryliverlymph nodebreaststomachprostate glandchesttrunkheadpancreasskin of bodyepitheliumbone marrowconnective tissueenamelspleenembryogerm layeruterine cervixepithelial cellgerminal epithelium of ovaryT cellmesodermcardiovascular systemameloblastnervous systemvermiform appendixrectumcaecummucosaurinary bladdercentral nervous systembrainepithelium of mammary glandfibroblastendometriummacrophagemouthsmall intestinethyroid glandtooth enamel organgallbladderheartthroatneckcalcareous toothB cellmusculature of bodyblood vesselmusculaturethyroid follicular cellskeletal jointdendritic cellbone elementstromal cellbronchusgranulocytephagocytevertebral columnmanual digitmanusalveolar ridgeblood plasmasmooth muscle tissueskin epidermisportal veinepidermal cellduodenumneutrophilendotheliumperitoneumabdomenkeratinocyteoocyteendothelial cellurotheliumstratum spinosum of epidermisepithelium of bronchusectodermcartilage tissuemammary glandforelimbmononuclear celltonsilchondrocytesalivaveinadrenal glandretinavaginanasopharynxchordate pharynxmouth mucosacardiac muscle celladipose tissueamygdalaangular gyrusanterior cingulate cortexanterior cingulate gyrusanteroventral cochlear nucleusventral funiculus of spinal cordinsular cortexventral anterior nucleus of thalamusarcuate nucleusextrastriate cortexarea postremaprimary visual cortexcaudate nucleuscentral medial nucleuscerebellar cortexcerebellar nuclear complexwhite matter of cerebellumcervical spinal cordchoroid plexusclaustrum of braincorpus callosumcorticomedial nuclear complexcuneate nucleuscuneiform nucleusdentate gyrus of hippocampal formationdorsal cochlear nucleusdorsal funiculus of spinal cordmedullary reticular formationdorsal motor nucleus of vagus nervedorsal raphe nucleusdorsal tegmental nucleusdorsolateral prefrontal cortexmidbrain tegmentumdorsomedial nucleus of hypothalamusprefrontal cortexentorhinal cortexepididymisfallopian tubeflocculonodular lobefrontal cortexfrontal operculumfrontomarginal sulcusfrontopolar cortexfusiform gyrusglobus pallidusgyrus rectushabenulacardiac muscle tissuehippocampal formationCA1 field of hippocampusCA2 field of hippocampusCA3 field of hippocampusinferior colliculusinferior frontal gyrusinferior olivary complexinferior parietal cortexinferior temporal gyrusintraparietal sulcuspontine nuclear grouplateral amygdaloid nucleuslateral funiculus of spinal cordlateral geniculate bodylateral hypothalamic areanucleus of lateral lemniscuslateral reticular nucleuslateral parabrachial nucleuslateral nuclear group of thalamuslateral vestibular nucleuslingual gyruslocus ceruleusmammillary bodymedial dorsal nucleus of thalamusmedial geniculate bodymedial superior olivary nucleusmedial parabrachial nucleusperiolivary nucleusmedial vestibular nucleusmedian raphe nucleuscingulate cortexmiddle frontal gyrusmiddle temporal gyrusfacial motor nucleushypoglossal nucleusmotor nucleus of trigeminal nervenucleus of trapezoid bodynucleus accumbensnucleus ambiguusbasal nucleus of telencephalongracile nucleusnucleus of diagonal bandnucleus raphe magnusnucleus raphe obscurusnucleus raphe pallidusreuniens nucleusrhomboidal nucleusnucleus of solitary tractoccipital cortexolfactory entorhinal cortexolfactory tubercleorbitofrontal cortexparacentral lobuleparahippocampal gyrusparamedian reticular nucleusparathyroid glandparaventricular nucleus of hypothalamusparietal cortexparietal operculumparieto-insular cortexparieto-occipital sulcustemporoparietal junctionparvocellular reticular nucleuspedunculopontine tegmental nucleuscentral gray substance of midbrainperirhinal cortexperitrigeminal nucleuspiriform cortexpontine raphe nucleuspostcentral gyrusposterior cingulate cortexposterior nucleus of thalamusposteroventral cochlear nucleusprecentral gyrusprecuneus cortexpremotor cortexpreoptic areanucleus preposituspretectal regionprincipal sensory nucleus of trigeminal nervepulvinar nucleusputamenred nucleuscaudal pontine reticular nucleusoral pontine reticular nucleusreticulotegmental nucleusretrosplenial regionsaliva-secreting glandseminal vesicleseptal nuclear complexskeletal muscle tissuesomatosensory cortexcaudal part of spinal trigeminal nucleusinterpolar part of spinal trigeminal nucleusoral part of spinal trigeminal nucleusvestibular nucleusstria terminalissubcallosal areasubcentral gyrus, S2subiculumsubstantia nigrasubthalamic nucleussuperior colliculussuperior frontal gyrussuperior olivary complexsuperior parietal cortexsuperior temporal gyrussuperior vestibular nucleussupplemental motor cortexsupramarginal gyrussupraoptic nucleustemporal cortextemporal polewhite matter of temporal lobetemporo-occipital transitional zonethymustongueanterior transverse temporal gyrusposterior transverse temporal gyrusventral posterolateral nucleusventral posteromedial nucleus of thalamusventral tegmental areaventral nuclear groupventrolateral medulla, A1-C1 cell groupsventromedial nucleus of hypothalamuscerebellar vermiszona incertaspinal cordB CellsCD4 CellsCD8 Cellspresumptive gutMonocytesNK CellsPlateletspituitary glandsuprapubic skintransverse colontibial nerveC1 segment of cervical spinal cordAmmon's hornouter medulla of kidneycerebellumsigmoid coloncortex of kidneyright lobe of liverleft ventricle myocardiumgastroesophageal sphincterbody of pancreashypothalamusectocervixendocervixsubcutaneous adipose tissueesophagus muscularis mucosaanterior lingual glandright atrium auricular regionbreast epitheliumCells - Cultured fibroblastsvenous bloodtibial arterygastrocnemius medialisPeyer's patchlower leg skinupper lobe of left lungcoronary arteryesophagus squamous epitheliumascending aortaomental fat padCells - EBV-transformed lymphocytes
root: immaterial entity (BFO:0000141)
Reset Zoom
root: material entity (BFO:0000040)
Reset Zoom
Coexpression Data
Tissue Specific Coexpression (520)
Illuminating Dark Proteins using Reactome Pathways.
Brunson et al., bioRxiv : the preprint server for biology, 2023-06-05
Items per page:
5
1 – 5 of 520
Coexpressed Target
Data Source
Tissue
GTEx
Cells-Culturedfibroblasts
GTEx
Cells-Culturedfibroblasts
GTEx
Cells-Culturedfibroblasts
GTEx
Cells-Culturedfibroblasts
GTEx
Cells-Culturedfibroblasts
Cancer Specific Coexpression (1316)
Items per page:
5
1 – 5 of 1316
Coexpressed Target
Data Source
Cancer Type
TCGA
KICH
TCGA
KICH
TCGA
KICH
TCGA
KICH
TCGA
KICH
Protein Sequence and Structure
Residue Counts
LSEAGPVKRTQDIFNYHCMW05101520253035404550556065
Protein Sequence
ProtVista Viewer
Related Tools (5)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (120)
1 – 10 of 120
BACH1
Tbio
IDG Family:  TF
Novelty:  0.04011328
p_int:  0.999998602
p_ni:  0.000001398
Score:  0.203
Data Source:  BioPlex,STRINGDB
HMMR
Tchem
Novelty:  0.0039196
p_int:  0.999995397
p_ni:  0.000004603
Score:  0.971
Data Source:  BioPlex,STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.999584273
p_ni:  0.000415727
Data Source:  BioPlex
ZAR1L
Tdark
Novelty:  0.08793345
p_int:  0.999576482
p_ni:  0.000423518
Data Source:  BioPlex
CSNK1A1
Tchem
IDG Family:  Kinase
Novelty:  0.00636472
p_int:  0.998946167
p_ni:  0.001053833
Score:  0.566
Data Source:  BioPlex,STRINGDB
CCDC40
Tbio
Novelty:  0.06726469
p_int:  0.99880831
p_ni:  0.00119169
Score:  0.625
Data Source:  BioPlex,STRINGDB
GMNN
Tbio
Novelty:  0.00436572
p_int:  0.997443058
p_ni:  0.002556942
Score:  0.356
Data Source:  BioPlex,STRINGDB
PSMC3
Tbio
IDG Family:  Enzyme
Novelty:  0.04026019
p_int:  0.993376245
p_ni:  0.006623754
Data Source:  BioPlex
TRAK2
Tbio
Novelty:  0.04192075
p_int:  0.984132662
p_ni:  0.01585552
p_wrong:  0.000011818
Data Source:  BioPlex
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.973404322
p_ni:  0.026594436
p_wrong:  0.000001242
Data Source:  BioPlex
Predicted Interactions
Nearest Tclin Targets
Nearest Tclin calculations are only available for non-Tclin targets that have KEGG Pathway annotations.
Pathways (0)
No pathways found
Interacting Pathways
Reactome is a manually curated, peer reviewed knowledgebase of human biological pathways and processes, available online as an open access resource that can be freely used and distributed by all members of the biological research community. This view of the Reactome database displays the pathways functionally interacting with FAM83D.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Items per page:
5
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (27)
1 – 10 of 27
Predicted Diseases
No data found
Disease Novelty (TIN-X)
none
1.00000µ100.000µ10.0000m1.00000100.000Novelty1.00000m10.0000m100.000m1.00000Importance
root: disease (DOID:4)
Reset Zoom
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
81.3
none
81Mean Rank Score3.03.54.04.55.0Beta Count
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919128
71878
Rat
RGD:1565583
311598
Dog
family with sequence similarity 83 member D
VGNC:40702
100683673
Horse
family with sequence similarity 83 member D
VGNC:17890
100070299
Cow
family with sequence similarity 83 member D
VGNC:28835
508561
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
family with sequence similarity 83 member D
Horse
family with sequence similarity 83 member D
Cow
family with sequence similarity 83 member D
Publication Statistics
PubMed Score 39.37
PubMed score by year
none
20002005201020152020Year0123456Score
PubTator Score 36.67
PubTator score by year
none
19801985199019952000200520102015Year012345Score
Publications (32)
Overrepresented Terms from Abstracts 100 terms from up to 100 abstracts, scaled based on the degree of overrepresentation (Fisher's Exact Test p-Value).
similarityCHICAFAM83spindlesequencemitoticTQTspindlesDUF1669FAM83BFAM83AMGCAnnotationmemberspindle-associatedcorrectmicrotubulesTCGAInteractomeslocalisesdivisionInstituteshepatocellularCK1DFScaseinnetworksmetaphaseoncogenecollectionhelpsfamilyprojectpipelineOSchromatidsHCCFBXW7accuracyorganizepromotedpolescompriseshighlycompleteAtlasORFAFPPubliclycDNAsOmnibusErrorsGEOplateadvancemitosissetapproachGOreadingcancersanchorproperSurveysistercelllibrariessequencedNationaltypescolonyavailableoverallcancerorientationfailknockdownclonesapparatusobviousthem
Items per page:
1 – 5 of 32
METTL3 regulates FAM83D m6A modification to accelerate tumorigenesis of triple-negative breast cancer via the Wnt/β-catenin pathway.
Yu et al., Toxicology in vitro : an international journal published in association with BIBRA, 2024-03
Abstract: (show)
N6-methyladenosine (m6A) modification, the most abundant methylation modification on eukaryotic mRNAs, was implicated in the tumourigenesis. This study aimed to explore the role of methyltransferase like 3 (METTL3) in triple-negative breast cancer progression and its underlying mechanisms. FAM83D was markedly elevated in triple-negative breast cancer tissues and cells, and high expression of FAM83D was related to the poor prognosis of triple-negative breast cancer patients. FAM83D knockdown significantly retarded cell proliferation, invasion, stemness, and accelerated cell apoptosis in triple-negative breast cancer cells. On the contrary, overexpression of FAM83D promoted the malignant behaviors. METTL3 could interact with FAM83D and mediate m6A modification of FAM838D. Moreover, METTL3 positively regulated FAM83D expression, and FAM83D overexpression could block the inhibition effects of MRTTL3 knockdown on the malignant behaviors. METTL3 knockdown decreased FAM83D expression to inhibit the Wnt/β-catenin pathway. In addition, knockdown of FAM83D also showed the repressive effects on tumor growth in triple-negative breast cancer in vivo. These findings suggested that METTL3 could modulate FAM83D protein expression through m6A modification to aggravate triple-negative breast cancer progression via the Wnt/β-catenin pathway.
Abstract: (show)
Family with sequence similarity of 83D (FAM83D) is overexpressed in various cancers. However, no pan-cancer analysis is presently available. In the present study, we used a bioinformatics analysis to explore the diagnostic and prognostic value of FAM83D expression levels in human cancers. The GEPIA 2, TIMER 2.0, ENCORI, and DriverDBV3 databases were used to evaluate FAM83D expression levels. The potential prognostic value of FAM83D expression was analyzed using the GEPIA 2, UALCAN, and TISIB databases. The driver gene and promoter methylation levels regarding FAM83D were evaluated using the TIMER 2.0 and UALCAN databases. To further analyze interactive networks for FAM83D, FAM83D-binding proteins and related genes were determined using STRING and Gene MANIA analytic tools. Highly expressed FAM83D could be associated with mutated TP53 and promoter DNA methylation. Relative network analysis suggested that FAM83D was mainly involved in the progesterone-mediated oocyte maturation pathway, cell cycle regulation, and several other signaling pathways. Therefore, the differential expression of FAM83D could serve as a diagnostic and prognostic biomarker for various cancers. Our study revealed useful information about the differential expression of FAM83D, prognostic values, and potential functional networks in a variety of cancers, providing valuable substantive and methodological information to explore the underlying mechanisms.Abbreviations: BP: Biological processes; CC: Cellular components; DAVID: Database for Annotation, Visualization, and Integrated Discovery; DFS: Disease-free survival; ENCORI: Encyclopedia of RNA Interactomes; FAM83: Family with sequence similarity 83; FAM83D: Family with sequence similarity of 83D; GEO: Gene Expression Omnibus; GEPIAx2: Gene Expression Profiling Interactive Analysis 2; GO: Gene Ontology; GTEx: Genotype-Tissue Expression; KEGG: Kyoto Encyclopedia of Genes and Genomes; KIRC: Kidney renal clear cell carcinoma; LIHC: Liver hepatocellular carcinoma; LUAD: Lung adenocarcinoma; MF: Molecular functions miRNA: microRNA; OS: Overall survival; PAAD: Pancreatic adenocarcinoma; PPI: Protein - protein interaction; RNA-seq: RNA-sequencing; TCGA: The Cancer Genome Atlas; TIMER 2.0: Tumor Immune Estimation Resource 2.0; UALCAN: University of Alabama at Birmingham Cancer; UCEC: Uterine corpus endometrial carcinoma.
Abstract: (show)
FAM83D (family with sequence similarity 83, member D) is of particular interest in tumorigenesis and tumor progression. Ovarian cancer is the leading cause of cancer-related death in women all over the world. This study aims to research the association between FAM83D and ovarian cancer (OC).
Abstract: (show)
FAM83D has been demonstrated to contribute to tumorigenesis. However, its immune effects in hepatocellular carcinoma (HCC) have not been reported. This study aimed to identify the immune role of FAM83D in HCC. FAM83D was over-expressed in HCC and contributed to poor prognosis according to the results of data analysis based on The Cancer Genome Atlas (TCGA). Afterward, the levels of immune cells infiltration were found to be correlated with the expression level of FAM83D in HCC. Through TISIDB and cBioPortal network tools, a total of 82 FAM83D-associated genes were screened out, including 12 immunoinhibitors, 20 immunostimulators and 50 tightly co-expressed genes. TCGA cohort was divided into train set and test set on the basis of the proportion of 7:3. According to FAM83D-associated immunomodulators, a four gene predicted model was established using train set via the Cox regression analysis. Survival analysis demonstrated that the overall survival (OS) of high-risk HCC patients was poor compared with the patients in low-risk group. The reliability and predicted power of the risk-score model were identified by a receiver operating characteristic (ROC) curve. A risk-score based nomogram as well as a calibration curve, which were created could be used to anticipate patient's 1-year, 3-year and 5-year survival probabilities. The test set was used to validate these results. Our findings showed that the FAM83D gene was related with HCC immunity. The immune marker chosen could be a promising biomarker for HCC prognosis.
Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific.
Zouboulis et al., Journal of the European Academy of Dermatology and Venereology : JEADV, 2020-07
Abstract: (show)
Apocrine glands have been long considered as the initial targeted skin compartment in hidradenitis suppurativa/acne inversa (HS).