You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
FAM69A
Protein FAM69A

Protein Summary
Description
This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370310
  • ENSP00000359333
  • ENSG00000154511
  • ENST00000615519
  • ENSP00000483279

Symbol
  • FAM69A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
histone modification site profile
0.83
small molecule perturbation
0.71
transcription factor binding site profile
0.71
microRNA
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.78   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.78   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.997426703
p_ni:  0.002573297
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.99686182
p_ni:  0.00313818
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.993537262
p_ni:  0.006462738
Data Source:  BioPlex
LRRC52
Tbio
Family:  IC
Novelty:  0.15407898
p_int:  0.992438718
p_ni:  0.007551218
p_wrong:  0.000010064
Data Source:  BioPlex
ST8SIA4
Tbio
Family:  Enzyme
Novelty:  0.00338436
p_int:  0.988810159
p_ni:  0.011189841
Data Source:  BioPlex
HTR3C
Tchem
Family:  IC
Novelty:  0.112097
p_int:  0.987939219
p_ni:  0.012060781
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.987239352
p_ni:  0.012760648
Data Source:  BioPlex
PNLDC1
Tbio
Family:  Enzyme
Novelty:  0.16308361
p_int:  0.979659769
p_ni:  0.020340231
Data Source:  BioPlex
CD1E
Tbio
Novelty:  0.00171622
p_int:  0.97578332
p_ni:  0.02421668
Data Source:  BioPlex
GP9
Tbio
Novelty:  0.00365769
p_int:  0.97183917
p_ni:  0.028156669
p_wrong:  0.00000416
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
56.8
mean reticulocyte volume
1
1
1
50.6
body mass index
1
1
1
50.6
neutrophil count
2
2
2
49.4
reticulocyte measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
56.8
mean reticulocyte volume
1
50.6
body mass index
1
50.6
neutrophil count
2
49.4
reticulocyte measurement
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 69 member A
VGNC:6811
100613226
Macaque
family with sequence similarity 69 member A
706803
Mouse
MGI:1914516
67266
Rat
RGD:1308581
360906
Dog
family with sequence similarity 69 member A
VGNC:40691
100855467
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 69 member A
Macaque
family with sequence similarity 69 member A
Mouse
Rat
Dog
family with sequence similarity 69 member A
Publication Statistics
PubMed Score 2.78
PubMed score by year
PubTator Score 0.62
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title