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Tdark
FAM53A
Protein FAM53A

Protein Summary
Description
May play an important role in neural development; the dorsomedial roof of the third ventricle.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308132
  • ENSP00000310057
  • ENSG00000174137
  • ENST00000461064
  • ENSP00000418243
  • ENST00000472884
  • ENSP00000426260

Symbol
  • DNTNP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
tissue sample
0.71
transcription factor
0.7
cell type or tissue
0.68
transcription factor binding site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.91   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.91   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
TMEM129
Tbio
Family:  Enzyme
Novelty:  0.53527143
Score:  0.696
Data Source:  STRINGDB
CCDC189
Tdark
Novelty:  2.06975081
Score:  0.669
Data Source:  STRINGDB
IQCN
Tdark
Novelty:  2.74045479
Score:  0.543
Data Source:  STRINGDB
SLBP
Tbio
Novelty:  0.00685735
Score:  0.524
Data Source:  STRINGDB
TM2D1
Tdark
Novelty:  0.1760181
Score:  0.507
Data Source:  STRINGDB
FUT11
Tbio
Family:  Enzyme
Novelty:  0.16098097
Score:  0.504
Data Source:  STRINGDB
INTS4
Tdark
Novelty:  0.20868831
Score:  0.504
Data Source:  STRINGDB
SPATA2L
Tdark
Novelty:  1.32317574
Score:  0.493
Data Source:  STRINGDB
INTS3
Tbio
Novelty:  0.13398603
Score:  0.486
Data Source:  STRINGDB
LETM1
Tbio
Novelty:  0.01542461
Score:  0.478
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
9
9
90.6
6
3
3
1.1
88.6
4
2
0
1.2
79.3
serum gamma-glutamyl transferase measurement
1
1
1
64.9
mean reticulocyte volume
1
1
1
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
9
90.6
3
1.1
88.6
0
1.2
79.3
serum gamma-glutamyl transferase measurement
1
64.9
mean reticulocyte volume
1
63.7
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 53 member A
VGNC:10860
739145
Macaque
family with sequence similarity 53 member A
722555
Mouse
MGI:1919225
74504
Rat
RGD:1563315
305461
Dog
family with sequence similarity 53 member A
VGNC:53174
610722
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 53 member A
Macaque
family with sequence similarity 53 member A
Mouse
Rat
Dog
family with sequence similarity 53 member A
Publication Statistics
PubMed Score 2.91
PubMed score by year
PubTator Score 0.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title