Tdark FAM45A Protein FAM45A

Protein Summary

Uniprot Accession IDs

• Q8TCE6
• B1AMV6
• B4DDC3
• D3DRC8
• Q9NXW4

Gene Name

• FAM45A

Ensembl ID

• ENST00000361432
• ENSP00000354688
• ENSG00000119979

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
kinase perturbation	0.84
disease perturbation	0.79
histone modification site profile	0.7
small molecule perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.21   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 41   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.21   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (40)

Explore Interacting Targets

1 – 10 of 40

• See Interactions on String-DB

COMMD1

Tbio

Novelty:  0.01349432

p_int:  1

Score:  0.847

Data Source:  BioPlex,STRINGDB

COMMD10

Tbio

Novelty:  0.29057641

p_int:  1

Score:  0.835

Data Source:  BioPlex,STRINGDB

COMMD3

Tbio

Novelty:  0.07399068

p_int:  1

Score:  0.834

Data Source:  BioPlex,STRINGDB

COMMD6

Tbio

Novelty:  0.11854363

p_int:  1

Score:  0.822

Data Source:  BioPlex,STRINGDB

CCDC22

Tbio

Novelty:  0.01400901

p_int:  1

Score:  0.817

Data Source:  BioPlex,STRINGDB

FAM45BP

Tdark

p_int:  1

Data Source:  BioPlex

COMMD8

Tdark

Novelty:  0.33240242

p_int:  0.999999999

p_ni:  1e-9

Score:  0.815

Data Source:  BioPlex,STRINGDB

COMMD2

Tdark

Novelty:  0.62195903

p_int:  0.999999995

p_ni:  5e-9

Score:  0.824

Data Source:  BioPlex,STRINGDB

COMMD4

Tbio

Novelty:  0.20453574

p_int:  0.999999981

p_ni:  1.9e-8

Score:  0.866

Data Source:  BioPlex,STRINGDB

COMMD9

Tdark

Novelty:  0.77223999

p_int:  0.999993872

p_ni:  0.000006128

Score:  0.869

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (0)

No GO Terms found

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Keratoconus	Orphanet_156071	1	1	1		53.3
neutrophil count	EFO_0004833	1	1	1		50.6
platelet crit	EFO_0007985	1	1	1		45.7
myeloid white cell count	EFO_0007988	1	1	1		45.2
BMI-adjusted waist circumference	EFO_0007789	1	1	1		21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Keratoconus	Orphanet_156071	1		53.3
neutrophil count	EFO_0004833	1		50.6
platelet crit	EFO_0007985	1		45.7
myeloid white cell count	EFO_0007988	1		45.2
BMI-adjusted waist circumference	EFO_0007789	1		21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
Keratoconus
myeloid white cell count
neutrophil count
platelet crit

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	family with sequence similarity 45 member A		465955
Mouse	family with sequence similarity 45, member A	MGI:1915144	67894
Dog	family with sequence similarity 45 member A	VGNC:52990	477837
Horse	family with sequence similarity 45 member A [Source:HGNC Symbol;Acc:HGNC:31793]
Cow	family with sequence similarity 45 member A		534370

Species	Name	OMA	EggNOG	Inparanoid
Chimp	family with sequence similarity 45 member A
Mouse	family with sequence similarity 45, member A
Dog	family with sequence similarity 45 member A
Horse	family with sequence similarity 45 member A [Source:HGNC Symbol;Acc:HGNC:31793]
Cow	family with sequence similarity 45 member A

Publication Statistics

PubMed Score 1.21

PubMed score by year

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Related Publications

Text Mined References (6)

Items per page:

10

0 of 0

PMID	Year	Title