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Tdark
FAM43A
Protein FAM43A

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329759
  • ENSP00000371397
  • ENSG00000185112
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
transcription factor perturbation
0.84
histone modification site profile
0.61
small molecule perturbation
0.58
microRNA
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.09   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.09   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
PPP2R5E
Tbio
Family:  Enzyme
Novelty:  0.05974697
p_int:  0.999996459
p_ni:  0.000003541
Score:  0.185
Data Source:  BioPlex,STRINGDB
PPP2R5A
Tchem
Family:  Enzyme
Novelty:  0.03073487
p_int:  0.999910867
p_ni:  4.91e-7
p_wrong:  0.000088642
Score:  0.209
Data Source:  BioPlex,STRINGDB
PPP2R5B
Tbio
Family:  Enzyme
Novelty:  0.08980945
p_int:  0.999557776
p_ni:  5.7e-8
p_wrong:  0.000442167
Score:  0.268
Data Source:  BioPlex,STRINGDB
PPP2R5D
Tbio
Family:  Enzyme
Novelty:  0.03990599
p_int:  0.999127678
p_ni:  0.000863771
p_wrong:  0.000008552
Score:  0.177
Data Source:  BioPlex,STRINGDB
CLASP2
Tbio
Novelty:  0.0353308
p_int:  0.997388565
p_ni:  0.002607536
p_wrong:  0.000003899
Score:  0.243
Data Source:  BioPlex,STRINGDB
PPP2R5C
Tbio
Family:  Enzyme
Novelty:  0.03336609
p_int:  0.991609527
p_ni:  0.008390473
Score:  0.211
Data Source:  BioPlex,STRINGDB
WRAP53
Tbio
Family:  Enzyme
Novelty:  0.0204638
p_int:  0.916384228
p_ni:  0.083615772
Score:  0.243
Data Source:  BioPlex,STRINGDB
PPP2R1B
Tbio
Family:  Enzyme
Novelty:  0.03936638
p_int:  0.799789148
p_ni:  0.200210852
Score:  0.185
Data Source:  BioPlex,STRINGDB
SNX29
Tdark
Novelty:  0.22265562
Score:  0.719
Data Source:  STRINGDB
CCBE1
Tbio
Novelty:  0.03290164
Score:  0.607
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
81.2
hemoglobin measurement
2
2
2
81.1
reticulocyte measurement
3
3
3
79.8
reticulocyte count
2
1
2
70.2
eosinophil count
2
2
2
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
81.2
hemoglobin measurement
2
81.1
reticulocyte measurement
3
79.8
reticulocyte count
2
70.2
eosinophil count
2
60.2
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 43 member A
VGNC:6236
460945
Macaque
family with sequence similarity 43 member A
708207
Mouse
MGI:2676309
224093
Dog
family with sequence similarity 43 member A
VGNC:53072
102152951
Cow
family with sequence similarity 43 member A
VGNC:28813
539374
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 43 member A
Macaque
family with sequence similarity 43 member A
Mouse
Dog
family with sequence similarity 43 member A
Cow
family with sequence similarity 43 member A
Publication Statistics
PubMed Score 1.09
PubMed score by year
PubTator Score 0.42
PubTator score by year
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Related Publications
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PMID
Year
Title