Pharos : Target Details

Tdark

Protein Summary

Uniprot Accession IDs

Gene Name

FAM43A

Ensembl ID

ENST00000329759
ENSP00000371397
ENSG00000185112

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.85

transcription factor perturbation	0.84

histone modification site profile	0.61

small molecule perturbation	0.58

microRNA	0.55

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.09 (req: < 5)

View Publications

Gene RIFs: 0 (req: <= 3)

Antibodies: 28 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.09 (req: >= 5)

Gene RIFs: 0 (req: > 3)

Antibodies: 28 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (36)

Explore Interacting Targets

1 – 10 of 36

See Interactions on String-DB

PPP2R5E

Tbio

Family: Enzyme

Novelty: 0.05974697

p_int: 0.999996459

p_ni: 0.000003541

Score: 0.185

Data Source: BioPlex,STRINGDB

PPP2R5A

Tchem

Family: Enzyme

Novelty: 0.03073487

p_int: 0.999910867

p_ni: 4.91e-7

p_wrong: 0.000088642

Score: 0.209

Data Source: BioPlex,STRINGDB

PPP2R5B

Tbio

Family: Enzyme

Novelty: 0.08980945

p_int: 0.999557776

p_ni: 5.7e-8

p_wrong: 0.000442167

Score: 0.268

Data Source: BioPlex,STRINGDB

PPP2R5D

Tbio

Family: Enzyme

Novelty: 0.03990599

p_int: 0.999127678

p_ni: 0.000863771

p_wrong: 0.000008552

Score: 0.177

Data Source: BioPlex,STRINGDB

CLASP2

Tbio

Novelty: 0.0353308

p_int: 0.997388565

p_ni: 0.002607536

p_wrong: 0.000003899

Score: 0.243

Data Source: BioPlex,STRINGDB

PPP2R5C

Tbio

Family: Enzyme

Novelty: 0.03336609

p_int: 0.991609527

p_ni: 0.008390473

Score: 0.211

Data Source: BioPlex,STRINGDB

WRAP53

Tbio

Family: Enzyme

Novelty: 0.0204638

p_int: 0.916384228

p_ni: 0.083615772

Score: 0.243

Data Source: BioPlex,STRINGDB

PPP2R1B

Tbio

Family: Enzyme

Novelty: 0.03936638

p_int: 0.799789148

p_ni: 0.200210852

Score: 0.185

Data Source: BioPlex,STRINGDB

SNX29

Tdark

Novelty: 0.22265562

Score: 0.719

Data Source: STRINGDB

CCBE1

Tbio

Novelty: 0.03290164

Score: 0.607

Data Source: STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (0)

No GO Terms found

Disease Associations ()

No disease associations found

GWAS Traits (8)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
hematocrit	EFO_0004348	2	2	2	81.2

hemoglobin measurement	EFO_0004509	2	2	2	81.1

reticulocyte measurement	EFO_0010700	3	3	3	79.8

reticulocyte count	EFO_0007986	2	1	2	70.2

eosinophil count	EFO_0004842	2	2	2	60.2

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
hematocrit	EFO_0004348	2	81.2

hemoglobin measurement	EFO_0004509	2	81.1

reticulocyte measurement	EFO_0010700	3	79.8

reticulocyte count	EFO_0007986	2	70.2

eosinophil count	EFO_0004842	2	60.2

Beta Count

Odds Ratio

Find similar targets by:

UniProt Keyword

Find Similar Targets

GWAS Trait

Find Similar Targets

No Header	No Header
eosinophil count

eosinophil percentage of leukocytes

hematocrit

hemoglobin measurement

neutrophil count

neutrophil percentage of leukocytes

reticulocyte count

reticulocyte measurement

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID
Chimp	family with sequence similarity 43 member A	VGNC:6236	460945

Macaque	family with sequence similarity 43 member A		708207

Mouse	family with sequence similarity 43, member A	MGI:2676309	224093

Dog	family with sequence similarity 43 member A	VGNC:53072	102152951

Cow	family with sequence similarity 43 member A	VGNC:28813	539374

Species	Name	OMA	EggNOG	Inparanoid
Chimp	family with sequence similarity 43 member A

Macaque	family with sequence similarity 43 member A

Mouse	family with sequence similarity 43, member A

Dog	family with sequence similarity 43 member A

Cow	family with sequence similarity 43 member A

Publication Statistics

PubMed Score 1.09

PubMed score by year

PubTator Score 0.42

PubTator score by year

Related Publications

Text Mined References (5)

Items per page:

0 of 0

PMID	Year	Title