Protein Summary
May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]
- ENST00000359943
- ENSP00000353025
- ENSG00000196937
- ILEI
- ILEI
- GS3786
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
transcription factor binding site profile | 0.89 | ||
microRNA | 0.81 | ||
histone modification site profile | 0.76 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.84 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 247 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.84 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 247 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (59)
ST3GAL4
Family: Enzyme
Novelty: 0.00419433
p_int: 0.998400034
p_ni: 0.001104246
p_wrong: 0.000495721
Score: 0.183
Data Source: BioPlex,STRINGDB
LRRC52
Family: IC
Novelty: 0.15407898
p_int: 0.998135471
p_ni: 0.001864488
p_wrong: 4.1e-8
Data Source: BioPlex
IFNLR1
Novelty: 0.01990628
p_int: 0.997547146
p_ni: 0.002448787
p_wrong: 0.000004067
Data Source: BioPlex
B3GNT2
Family: Enzyme
Novelty: 0.02724566
p_int: 0.994769789
p_ni: 0.005229844
p_wrong: 3.67e-7
Score: 0.174
Data Source: BioPlex,STRINGDB
TMEM106A
Novelty: 0.32470607
p_int: 0.985819514
p_ni: 0.00669962
p_wrong: 0.007480866
Data Source: BioPlex
CHST6
Family: Enzyme
Novelty: 0.01917947
p_int: 0.984863453
p_ni: 0.010433398
p_wrong: 0.004703149
Score: 0.183
Data Source: BioPlex,STRINGDB
ADGRG5
Family: GPCR
Novelty: 0.26575982
p_int: 0.966257618
p_ni: 0.015406747
p_wrong: 0.018335635
Data Source: BioPlex
B3GALNT1
Family: Enzyme
Novelty: 0.01235828
p_int: 0.943027647
p_ni: 0.036084023
p_wrong: 0.02088833
Score: 0.166
Data Source: BioPlex,STRINGDB
PDCD1
Novelty: 0.000448
p_int: 0.920099728
p_ni: 0.079892058
p_wrong: 0.000008215
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Hemostasis | ||||
Reactome | Platelet activation, signaling and aggregation | ||||
Reactome | Platelet degranulation | ||||
Reactome | Response to elevated platelet cytosolic Ca2+ | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Hemostasis | ||||
Platelet activation, signaling and aggregation | ||||
Platelet degranulation | ||||
Response to elevated platelet cytosolic Ca2+ | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 24 | 39 | 99.9 | |||||
bone density | 13 | 9 | 17 | 99.2 | |||||
bone quantitative ultrasound measurement | 3 | 2 | 7 | 87.6 | |||||
BMI-adjusted waist-hip ratio | 3 | 3 | 3 | 81.7 | |||||
radius bone mineral density | 1 | 1 | 1 | 77.3 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 39 | 99.9 | |||||
bone density | 17 | 99.2 | |||||
bone quantitative ultrasound measurement | 7 | 87.6 | |||||
BMI-adjusted waist-hip ratio | 3 | 81.7 | |||||
radius bone mineral density | 1 | 77.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | family with sequence similarity 3 member C | VGNC:4351 | 463680 | |||||
Macaque | family with sequence similarity 3 member C | 694209 | ||||||
Mouse | MGI:107892 | 27999 | ||||||
Rat | RGD:735193 | 312159 | ||||||
Dog | family with sequence similarity 3 member C | VGNC:40679 | 612336 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | family with sequence similarity 3 member C | |||||
Macaque | family with sequence similarity 3 member C | |||||
Mouse | ||||||
Rat | ||||||
Dog | family with sequence similarity 3 member C | |||||
Publication Statistics
PubMed Score 24.84
PubMed score by year
PubTator Score 15.96
PubTator score by year
Related Publications
Text Mined References (32)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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