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Tbio
FAM3B
Protein FAM3B

Protein Summary
Description
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357985
  • ENSP00000350673
  • ENSG00000183844
  • ENST00000398647
  • ENSP00000381642
  • ENST00000398652
  • ENSP00000381646

Symbol
  • C21orf11
  • C21orf76
  • 2-21
  • ORF9
  • PANDER
  • PRED44
  • C21orf11
  • C21orf76
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.78
gene perturbation
0.63
transcription factor
0.5
cellular component
0.48
PubMedID
0.42


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.2   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.2   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
TM9SF4
Tbio
Novelty:  0.10441964
p_int:  0.999377621
p_ni:  0.000622379
Score:  0.29
Data Source:  BioPlex,STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
p_int:  0.994094227
p_ni:  0.005905715
p_wrong:  5.9e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
CARD19
Tbio
Family:  Enzyme
Novelty:  0.18215136
p_int:  0.974455831
p_ni:  0.002152084
p_wrong:  0.023392086
Score:  0.23
Data Source:  BioPlex,STRINGDB
GNPTAB
Tbio
Family:  Enzyme
Novelty:  0.00336101
p_int:  0.9397296
p_ni:  0.060270369
p_wrong:  3.1e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
LRP5
Tbio
Novelty:  0.00089807
p_int:  0.903337676
p_ni:  0.096662315
p_wrong:  9e-9
Data Source:  BioPlex
ANKRD46
Tbio
Novelty:  0.06546845
p_int:  0.801976796
p_ni:  0.181928548
p_wrong:  0.016094656
Score:  0.173
Data Source:  BioPlex,STRINGDB
CBWD1
Tbio
Novelty:  0.04321511
p_int:  0.770811374
p_ni:  0.229188626
Data Source:  BioPlex
MPLKIP
Tbio
Family:  Enzyme
Novelty:  0.01661924
Score:  0.775
Data Source:  STRINGDB
TMPRSS2
Tchem
Family:  Enzyme
Novelty:  0.00117884
Score:  0.706
Data Source:  STRINGDB
DNAJC28
Tbio
Novelty:  0.02849281
Score:  0.703
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
85.2
1
1
0
1.1
80.6
cancer biomarker measurement
1
1
1
74.6
fasting blood glucose measurement
1
1
1
65.6
glucose tolerance test
1
1
1
65.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
85.2
0
1.1
80.6
cancer biomarker measurement
1
74.6
fasting blood glucose measurement
1
65.6
glucose tolerance test
1
65.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 3 member B
VGNC:6440
458563
Macaque
family with sequence similarity 3 member B
722516
Mouse
MGI:1270150
52793
Rat
RGD:1311662
304050
Dog
family with sequence similarity 3 member B
VGNC:40678
478419
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 3 member B
Macaque
family with sequence similarity 3 member B
Mouse
Rat
Dog
family with sequence similarity 3 member B
Publication Statistics
PubMed Score 133.20
PubMed score by year
PubTator Score 40.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title