Protein Summary
Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.
- ENST00000263384
- ENSP00000263384
- ENSG00000105058
- ENST00000589852
- ENSP00000465969
- OTAG12
- OTAG12
- OTAG-12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.97 | ||
transcription factor binding site profile | 0.77 | ||
kinase perturbation | 0.71 | ||
histone modification site profile | 0.7 | ||
cellular component | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.68 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 45 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.68 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 45 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0