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Tdark
FAM221B
Protein FAM221B

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388950
  • ENSP00000373602
  • ENSG00000204930
  • ENST00000423537
  • ENSP00000415299

Symbol
  • C9orf128
  • C9orf128
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
histone modification site profile
0.61
PubMedID
0.54
cell line
0.53
cellular component
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.01   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.01   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (7)
RB1CC1
Tbio
Novelty:  0.00744817
p_int:  0.999999908
p_ni:  9.2e-8
Score:  0.23
Data Source:  BioPlex,STRINGDB
SMG6
Tbio
Family:  Enzyme
Novelty:  0.0217417
p_int:  0.999996443
p_ni:  0.000003557
Score:  0.214
Data Source:  BioPlex,STRINGDB
ATG13
Tbio
Novelty:  0.00951471
p_int:  0.999994961
p_ni:  0.000005033
p_wrong:  6e-9
Score:  0.29
Data Source:  BioPlex,STRINGDB
SELENOO
Tdark
Novelty:  0.02959704
p_int:  0.999988257
p_ni:  0.000011735
p_wrong:  9e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
EFNB3
Tbio
Novelty:  0.0120367
p_int:  0.996072754
p_ni:  0.003795222
p_wrong:  0.000132024
Score:  0.181
Data Source:  BioPlex,STRINGDB
ATG101
Tbio
Novelty:  0.03407206
p_int:  0.994271169
p_ni:  4.4e-8
p_wrong:  0.005728787
Score:  0.403
Data Source:  BioPlex,STRINGDB
TSC2
Tbio
Novelty:  0.00067416
p_int:  0.898948407
p_ni:  0.101051591
p_wrong:  2e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
64
body height
1
1
1
62.5
electrocardiography
1
1
36
56.8
heel bone mineral density
2
2
2
47.7
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
64
body height
1
62.5
electrocardiography
36
56.8
heel bone mineral density
2
47.7
1
40.7
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
family with sequence similarity 221 member B
695632
Mouse
MGI:2441678
242408
Rat
RGD:1310425
298398
Dog
family with sequence similarity 221 member B
VGNC:53501
474763
Cow
family with sequence similarity 221 member B
VGNC:28800
783189
Species
Name
OMA
EggNOG
Inparanoid
Macaque
family with sequence similarity 221 member B
Mouse
Rat
Dog
family with sequence similarity 221 member B
Cow
family with sequence similarity 221 member B
Publication Statistics
PubMed Score 0.01
PubMed score by year
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Related Publications
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0 of 0
PMID
Year
Title