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Tdark
FAM221A
Protein FAM221A

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344962
  • ENSP00000342576
  • ENSG00000188732
  • ENST00000409192
  • ENSP00000386927
  • ENST00000409994
  • ENSP00000386631

Symbol
  • C7orf46
  • C7orf46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.75
histone modification site profile
0.61
tissue sample
0.58
cell type or tissue
0.5
tissue
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.55   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.55   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
SNX6
Tbio
Novelty:  0.05909848
p_int:  0.975674127
p_ni:  0.024325873
p_wrong:  1e-9
Score:  0.248
Data Source:  BioPlex,STRINGDB
SNX5
Tbio
Novelty:  0.04075649
p_int:  0.918519791
p_ni:  0.081480201
p_wrong:  8e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
SNX2
Tbio
Novelty:  0.03880384
p_int:  0.895786181
p_ni:  0.104213787
p_wrong:  3.2e-8
Score:  0.228
Data Source:  BioPlex,STRINGDB
OR6T1
Tdark
Family:  oGPCR
Novelty:  35
Score:  0.668
Data Source:  STRINGDB
HEATR9
Tdark
Novelty:  0.71415315
Score:  0.595
Data Source:  STRINGDB
C4orf19
Tdark
Novelty:  2.1863624
Score:  0.588
Data Source:  STRINGDB
FAM219B
Tdark
Novelty:  5.26378794
Score:  0.558
Data Source:  STRINGDB
C17orf78
Tdark
Novelty:  4.29271752
Score:  0.549
Data Source:  STRINGDB
PSMG3
Tchem
Novelty:  0.01730294
Score:  0.526
Data Source:  STRINGDB
NKAIN4
Tdark
Family:  Enzyme
Novelty:  1.65380282
Score:  0.525
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
0
5.7
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
0
5.7
24.5
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 221 member A
VGNC:4350
463294
Macaque
family with sequence similarity 221 member A
704002
Mouse
MGI:2442161
231946
Rat
RGD:1563175
500118
Dog
family with sequence similarity 221 member A
VGNC:40669
482361
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 221 member A
Macaque
family with sequence similarity 221 member A
Mouse
Rat
Dog
family with sequence similarity 221 member A
Publication Statistics
PubMed Score 0.55
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title