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Tdark
FAM219A
Protein FAM219A

Protein Summary
Description
The protein encoded by this gene has homologs that have been identified in mouse, macaque, etc organisms. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297620
  • ENSP00000297620
  • ENSG00000164970
  • ENST00000445726
  • ENSP00000392452

Symbol
  • C9orf25
  • C9orf25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
co-expressed gene
0.69
histone modification site profile
0.64
microRNA
0.6
transcription factor binding site profile
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.07   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.07   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
NBN
Tbio
Novelty:  0.00759456
p_int:  0.999999916
p_ni:  4.7e-8
p_wrong:  3.6e-8
Score:  0.198
Data Source:  BioPlex,STRINGDB
RAD50
Tbio
Novelty:  0.02161298
p_int:  0.999991203
p_ni:  0.000008797
Data Source:  BioPlex
FBXO10
Tbio
Novelty:  0.18324932
p_int:  0.999977517
p_ni:  0.000022483
Score:  0.227
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999889296
p_ni:  0.000110704
Data Source:  BioPlex
MRE11
Tbio
Novelty:  0.01038348
p_int:  0.99971636
p_ni:  0.00028364
Score:  0.198
Data Source:  BioPlex,STRINGDB
MTA3
Tbio
Family:  TF
Novelty:  0.02667635
p_int:  0.999452342
p_ni:  0.000547658
Score:  0.638
Data Source:  BioPlex,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.999271104
p_ni:  0.00072364
p_wrong:  0.000005256
Data Source:  BioPlex
GPR37
Tbio
Family:  GPCR
Novelty:  0.02193644
p_int:  0.999247717
p_ni:  0.000750236
p_wrong:  0.000002048
Score:  0.802
Data Source:  BioPlex,STRINGDB
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.998144693
p_ni:  0.001855307
Data Source:  BioPlex
MTA1
Tbio
Family:  TF
Novelty:  0.00464618
p_int:  0.997456604
p_ni:  0.002543396
Score:  0.323
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
1
1
0
1.7
52.2
self reported educational attainment
1
1
1
26.6
mean arterial pressure
1
1
1
22.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
0
1.7
52.2
self reported educational attainment
1
26.6
mean arterial pressure
1
22.8
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 219 member A
VGNC:4693
745905
Macaque
family with sequence similarity 219 member A
700651
Mouse
MGI:1919151
71901
Rat
RGD:1588668
691024
Dog
family with sequence similarity 219 member A
VGNC:40668
474748
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 219 member A
Macaque
family with sequence similarity 219 member A
Mouse
Rat
Dog
family with sequence similarity 219 member A
Publication Statistics
PubMed Score 0.07
PubMed score by year
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Related Publications
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PMID
Year
Title