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Tbio
FAM210B
Protein FAM210B, mitochondrial

Protein Summary
Description
Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371384
  • ENSP00000360437
  • ENSG00000124098

Symbol
  • C20orf108
  • 5A3
  • C20orf108
  • dJ1167H4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
virus perturbation
0.88
cell type or tissue
0.8
microRNA
0.75
tissue sample
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.19   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.19   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
TIMM8A
Tbio
Family:  Enzyme
Novelty:  0.00954602
p_int:  0.999997518
p_ni:  0.000002482
Data Source:  BioPlex
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.999997155
p_ni:  0.000002824
p_wrong:  2.1e-8
Score:  0.151
Data Source:  BioPlex,STRINGDB
TSPAN1
Tbio
Novelty:  0.01547855
p_int:  0.999828325
p_ni:  0.00013642
p_wrong:  0.000035255
Data Source:  BioPlex
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.999752837
p_ni:  0.000246285
p_wrong:  8.78e-7
Data Source:  BioPlex
TSPAN17
Tdark
Novelty:  0.51639684
p_int:  0.999662309
p_ni:  0.000334249
p_wrong:  0.000003442
Score:  0.183
Data Source:  BioPlex,STRINGDB
RTN1
Tbio
Novelty:  0.01828064
p_int:  0.999627812
p_ni:  0.000371872
p_wrong:  3.16e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.999611314
p_ni:  0.000385374
p_wrong:  0.000003312
Data Source:  BioPlex
TM4SF20
Tbio
Novelty:  0.21582226
p_int:  0.997691042
p_ni:  0.000633784
p_wrong:  0.001675174
Score:  0.243
Data Source:  BioPlex,STRINGDB
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.996284431
p_ni:  0.003492037
p_wrong:  0.000223533
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.995291833
p_ni:  0.000823766
p_wrong:  0.003884401
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
80
platelet count
2
2
2
73.8
2
2
0
5.5
50.6
family history of Alzheimer’s disease
1
2
0
5.9
50.6
mean corpuscular hemoglobin concentration
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
80
platelet count
2
73.8
0
5.5
50.6
family history of Alzheimer’s disease
0
5.9
50.6
mean corpuscular hemoglobin concentration
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 210 member B
VGNC:6104
469979
Macaque
family with sequence similarity 210 member B
698314
Mouse
MGI:1914267
67017
Rat
RGD:1311378
296408
Dog
family with sequence similarity 210 member B
VGNC:40658
485939
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 210 member B
Macaque
family with sequence similarity 210 member B
Mouse
Rat
Dog
family with sequence similarity 210 member B
Publication Statistics
PubMed Score 4.19
PubMed score by year
PubTator Score 1.39
PubTator score by year
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Related Publications
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PMID
Year
Title