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Tdark
FAM20B
Glycosaminoglycan xylosylkinase

Protein Summary
Description
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263733
  • ENSP00000263733
  • ENSG00000116199

Symbol
  • KIAA0475
  • gxk1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
molecular function
0.86
transcription factor binding site profile
0.75
microRNA
0.74
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.63   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.63   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
P2RX4
Tchem
Family:  IC
Novelty:  0.00242958
p_int:  0.999499577
p_ni:  0.000500417
p_wrong:  6e-9
Score:  0.518
Data Source:  BioPlex,STRINGDB
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.996205949
p_ni:  0.003794051
Score:  0.155
Data Source:  BioPlex,STRINGDB
ASPHD2
Tdark
Family:  Enzyme
Novelty:  1.24088719
p_int:  0.99456963
p_ni:  0.005430348
p_wrong:  2.1e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
TMEM130
Tdark
Novelty:  1.39618601
p_int:  0.993139349
p_ni:  0.006806759
p_wrong:  0.000053892
Data Source:  BioPlex
PVR
Tbio
Novelty:  0.00215811
p_int:  0.977603128
p_ni:  0.022396125
p_wrong:  7.47e-7
Data Source:  BioPlex
GALNT6
Tbio
Family:  Enzyme
Novelty:  0.04627605
p_int:  0.963643147
p_ni:  0.036354103
p_wrong:  0.00000275
Score:  0.32
Data Source:  BioPlex,STRINGDB
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.957589654
p_ni:  0.042410346
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.950543829
p_ni:  0.049448241
p_wrong:  0.00000793
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.924276638
p_ni:  0.075720623
p_wrong:  0.000002739
Data Source:  BioPlex
CLEC2B
Tbio
Novelty:  0.06581244
p_int:  0.876614001
p_ni:  0.123385464
p_wrong:  5.35e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
15.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FAM20B, glycosaminoglycan xylosylkinase
VGNC:6806
457550
Macaque
FAM20B, glycosaminoglycan xylosylkinase
717134
Mouse
MGI:2443990
215015
Rat
RGD:1311162
304885
Dog
FAM20B, glycosaminoglycan xylosylkinase
VGNC:40655
480053
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FAM20B, glycosaminoglycan xylosylkinase
Macaque
FAM20B, glycosaminoglycan xylosylkinase
Mouse
Rat
Dog
FAM20B, glycosaminoglycan xylosylkinase
Publication Statistics
PubMed Score 18.63
PubMed score by year
PubTator Score 4.08
PubTator score by year
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Related Publications
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PMID
Year
Title