You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FAM20A
Pseudokinase FAM20A

Protein Summary
Description
Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. This locus encodes a protein that is likely secreted and may function in hematopoiesis. A mutation at this locus has been associated with amelogenesis imperfecta and gingival hyperplasia syndrome. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000592554
  • ENSP00000468308
  • ENSG00000108950

Symbol
  • AI1G
  • AIGFS
  • FP2747
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
microRNA
0.64
histone modification site profile
0.63
cell line
0.62
tissue sample
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.17   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.17   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
FAM20C
Tbio
Family:  Enzyme
Novelty:  0.00318966
Score:  0.988
Data Source:  Reactome,STRINGDB
ENAM
Tbio
Novelty:  0.00593293
Score:  0.983
Data Source:  STRINGDB
AMTN
Tbio
Novelty:  0.02514528
Score:  0.975
Data Source:  STRINGDB
AMBN
Tbio
Novelty:  0.00354946
Score:  0.972
Data Source:  STRINGDB
AMELX
Tbio
Novelty:  0.00063284
Score:  0.963
Data Source:  STRINGDB
FGF23
Tclin
Novelty:  0.00047318
Score:  0.952
Data Source:  STRINGDB
AHSG
Tbio
Novelty:  0.00112502
Score:  0.947
Data Source:  STRINGDB
SPP1
Tbio
Novelty:  0.00014418
Score:  0.945
Data Source:  STRINGDB
F5
Tbio
Novelty:  0.00161772
Score:  0.925
Data Source:  STRINGDB
MEPE
Tbio
Novelty:  0.00825085
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
4
91.2
alkaline phosphatase measurement
2
2
1
6.9
89.2
glomerular filtration rate
4
3
4
83.1
heel bone mineral density
2
2
2
81.7
vitamin D measurement
3
3
3
81.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
91.2
alkaline phosphatase measurement
1
6.9
89.2
glomerular filtration rate
4
83.1
heel bone mineral density
2
81.7
vitamin D measurement
3
81.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FAM20A, golgi associated secretory pathway pseudokinase
VGNC:14191
454846
Mouse
MGI:2388266
208659
Rat
RGD:1306364
303635
Dog
FAM20A, golgi associated secretory pathway pseudokinase
VGNC:40654
480458
Horse
FAM20A, golgi associated secretory pathway pseudokinase
VGNC:17848
100062707
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FAM20A, golgi associated secretory pathway pseudokinase
Mouse
Rat
Dog
FAM20A, golgi associated secretory pathway pseudokinase
Horse
FAM20A, golgi associated secretory pathway pseudokinase
Publication Statistics
PubMed Score 34.17
PubMed score by year
PubTator Score 18.16
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title