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Tbio
FAM208A
Protein TASOR

Protein Summary
Description
Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355628
  • ENSP00000347845
  • ENSG00000163946
  • ENST00000431842
  • ENSP00000399410
  • ENST00000493960
  • ENSP00000417509

Symbol
  • C3orf63
  • KIAA1105
  • TASOR
  • RAP140
  • TASOR1
  • se89-1
  • C3orf63
  • FAM208A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
histone modification site profile
0.81
microRNA
0.79
disease perturbation
0.74
tissue
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.91   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.91   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.998487305
p_ni:  0.001512695
Data Source:  BioPlex
KLHL40
Tbio
Novelty:  0.0432945
p_int:  0.99582884
p_ni:  0.00417116
Data Source:  BioPlex
CIB2
Tbio
Novelty:  0.03578691
p_int:  0.994574981
p_ni:  0.005425018
p_wrong:  2e-9
Data Source:  BioPlex
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.98390314
p_ni:  0.01609686
Data Source:  BioPlex
FAM131B
Tdark
Novelty:  0.3424123
p_int:  0.973311315
p_ni:  0.026688678
p_wrong:  7e-9
Data Source:  BioPlex
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.9730663
p_ni:  0.0269337
Data Source:  BioPlex
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.955062555
p_ni:  0.044937443
p_wrong:  2e-9
Data Source:  BioPlex
RAD9B
Tdark
Novelty:  0.38973762
p_int:  0.954844575
p_ni:  0.045155425
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.934936864
p_ni:  0.065063136
Score:  0.184
Data Source:  BioPlex,STRINGDB
CORO1A
Tbio
Novelty:  0.00898925
p_int:  0.92964
p_ni:  0.07025193
p_wrong:  0.00010807
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
3
3
92.8
hemoglobin measurement
3
3
3
92.6
mean platelet volume
2
3
3
92.3
body height
4
2
4
86.3
platelet count
1
1
1
81.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
92.8
hemoglobin measurement
3
92.6
mean platelet volume
3
92.3
body height
4
86.3
platelet count
1
81.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 208 member A
VGNC:6234
747105
Macaque
family with sequence similarity 208 member A
708452
Mouse
MGI:1921694
218850
Rat
RGD:1595469
680155
Dog
family with sequence similarity 208 member A
VGNC:40652
476580
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 208 member A
Macaque
family with sequence similarity 208 member A
Mouse
Rat
Dog
family with sequence similarity 208 member A
Publication Statistics
PubMed Score 7.91
PubMed score by year
PubTator Score 2.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title