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Tdark
FAM19A5
Protein FAM19A5

Protein Summary
Description
Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By similarity). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity). This gene is a member of the TAFA family which is composed of five highl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358295
  • ENSP00000351043
  • ENSG00000219438
  • ENST00000402357
  • ENSP00000383933
  • ENST00000406880
  • ENSP00000385603

Symbol
  • TAFA5
  • TAFA-5
  • FAM19A5
  • UNQ5208
  • QLLK5208
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
trait
0.93
cell type or tissue
0.87
tissue sample
0.72
transcription factor
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.21   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.21   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
LRRC4B
Tbio
Novelty:  0.21762254
p_int:  0.999999571
p_ni:  4.29e-7
Score:  0.294
Data Source:  BioPlex,STRINGDB
NEBL
Tbio
Novelty:  0.02155964
p_int:  0.999899698
p_ni:  2e-9
p_wrong:  0.0001003
Data Source:  BioPlex
DCBLD2
Tbio
Novelty:  0.06514947
p_int:  0.998709648
p_ni:  0.001290237
p_wrong:  1.14e-7
Data Source:  BioPlex
PLTP
Tbio
Novelty:  0.00267612
p_int:  0.998676498
p_ni:  0.001323501
Data Source:  BioPlex
VWDE
Tdark
Novelty:  0.37298162
p_int:  0.998470714
p_ni:  0.001527832
p_wrong:  0.000001454
Data Source:  BioPlex
SDK2
Tdark
Novelty:  0.08867136
p_int:  0.989830516
p_ni:  0.010169483
p_wrong:  2e-9
Data Source:  BioPlex
FREM2
Tbio
Novelty:  0.03382033
p_int:  0.987727072
p_ni:  0.012272928
Data Source:  BioPlex
TENM3
Tbio
Novelty:  0.0251948
p_int:  0.987421515
p_ni:  0.012575595
p_wrong:  0.00000289
Data Source:  BioPlex
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.979275323
p_ni:  0.020724677
Data Source:  BioPlex
NLGN1
Tbio
Family:  Enzyme
Novelty:  0.0097512
p_int:  0.962515122
p_ni:  0.010361728
p_wrong:  0.027123151
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
44.2
body mass index
1
1
1
10.7
self reported educational attainment
1
1
1
7.2
high density lipoprotein cholesterol measurement
1
1
1
5.1
1
1
1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
44.2
body mass index
1
10.7
self reported educational attainment
1
7.2
high density lipoprotein cholesterol measurement
1
5.1
1
2.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 19 member A5, C-C motif chemokine like
VGNC:12874
737518
Mouse
MGI:2146182
106014
Rat
RGD:1562115
500915
Dog
family with sequence similarity 19 member A5, C-C motif chemokine like [Source:HGNC Symbol;Acc:HGNC:21592]
Cow
family with sequence similarity 19 member A5, C-C motif chemokine like
VGNC:28779
767927
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 19 member A5, C-C motif chemokine like
Mouse
Rat
Dog
family with sequence similarity 19 member A5, C-C motif chemokine like [Source:HGNC Symbol;Acc:HGNC:21592]
Cow
family with sequence similarity 19 member A5, C-C motif chemokine like
Publication Statistics
PubMed Score 17.21
PubMed score by year
PubTator Score 1.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title