You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FAM19A4
Protein FAM19A4

Protein Summary
Description
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295569
  • ENSP00000295569
  • ENSG00000163377

Symbol
  • TAFA4
  • TAFA-4
  • FAM19A4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
gene perturbation
0.65
phenotype
0.53
cell line
0.49
microRNA
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.41   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.41   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
Q9HDB5
Tbio
Novelty:  0.00999084
p_int:  0.999999415
p_ni:  5.85e-7
Score:  0.193
Data Source:  BioPlex,STRINGDB
SEZ6L2
Tbio
Novelty:  0.02623263
p_int:  0.999995925
p_ni:  0.000004075
Score:  0.172
Data Source:  BioPlex,STRINGDB
AVL9
Tbio
Novelty:  0.14044287
p_int:  0.999994879
p_ni:  3.3e-7
p_wrong:  0.000004791
Score:  0.232
Data Source:  BioPlex,STRINGDB
VCAN
Tbio
Novelty:  0.00110986
p_int:  0.999990262
p_ni:  0.000009714
p_wrong:  2.4e-8
Score:  0.175
Data Source:  BioPlex,STRINGDB
LRRC4B
Tbio
Novelty:  0.21762254
p_int:  0.999983758
p_ni:  0.000015995
p_wrong:  2.46e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
PLXNA2
Tbio
Novelty:  0.01765957
p_int:  0.99992763
p_ni:  0.00007237
Data Source:  BioPlex
SUSD5
Tdark
Novelty:  1.0992718
p_int:  0.999904712
p_ni:  0.000095285
p_wrong:  2e-9
Data Source:  BioPlex
MRC2
Tbio
Novelty:  0.01100289
p_int:  0.999901678
p_ni:  0.000098322
Score:  0.236
Data Source:  BioPlex,STRINGDB
TM7SF3
Tbio
Novelty:  0.12188681
p_int:  0.999898124
p_ni:  0.000018026
p_wrong:  0.000083851
Score:  0.232
Data Source:  BioPlex,STRINGDB
LIFR
Tbio
Novelty:  0.00514085
p_int:  0.999894782
p_ni:  0.000077661
p_wrong:  0.000027557
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
1
63.1
optic disc area measurement
1
1
2
52.7
self reported educational attainment
1
1
1
33.1
diet measurement
1
1
1
29
neuroticism measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
63.1
optic disc area measurement
2
52.7
self reported educational attainment
1
33.1
diet measurement
1
29
neuroticism measurement
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 19 member A4, C-C motif chemokine like
VGNC:10479
736206
Macaque
family with sequence similarity 19 member A4, C-C motif chemokine like
696987
Mouse
MGI:2444563
320701
Rat
RGD:1597443
689043
Dog
family with sequence similarity 19 member A4, C-C motif chemokine like
VGNC:40648
610997
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 19 member A4, C-C motif chemokine like
Macaque
family with sequence similarity 19 member A4, C-C motif chemokine like
Mouse
Rat
Dog
family with sequence similarity 19 member A4, C-C motif chemokine like
Publication Statistics
PubMed Score 29.41
PubMed score by year
PubTator Score 9.73
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title