Protein Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
- ENST00000295569
- ENSP00000295569
- ENSG00000163377
- TAFA4
- TAFA-4
- FAM19A4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.84 | ||
gene perturbation | 0.65 | ||
phenotype | 0.53 | ||
cell line | 0.49 | ||
microRNA | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.41 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 103 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.41 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 103 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (76)
Q9HDB5
Novelty: 0.00999084
p_int: 0.999999415
p_ni: 5.85e-7
Score: 0.193
Data Source: BioPlex,STRINGDB
SEZ6L2
Novelty: 0.02623263
p_int: 0.999995925
p_ni: 0.000004075
Score: 0.172
Data Source: BioPlex,STRINGDB
AVL9
Novelty: 0.14044287
p_int: 0.999994879
p_ni: 3.3e-7
p_wrong: 0.000004791
Score: 0.232
Data Source: BioPlex,STRINGDB
VCAN
Novelty: 0.00110986
p_int: 0.999990262
p_ni: 0.000009714
p_wrong: 2.4e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
LRRC4B
Novelty: 0.21762254
p_int: 0.999983758
p_ni: 0.000015995
p_wrong: 2.46e-7
Score: 0.183
Data Source: BioPlex,STRINGDB
SUSD5
Novelty: 1.0992718
p_int: 0.999904712
p_ni: 0.000095285
p_wrong: 2e-9
Data Source: BioPlex
MRC2
Novelty: 0.01100289
p_int: 0.999901678
p_ni: 0.000098322
Score: 0.236
Data Source: BioPlex,STRINGDB
TM7SF3
Novelty: 0.12188681
p_int: 0.999898124
p_ni: 0.000018026
p_wrong: 0.000083851
Score: 0.232
Data Source: BioPlex,STRINGDB
LIFR
Novelty: 0.00514085
p_int: 0.999894782
p_ni: 0.000077661
p_wrong: 0.000027557
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (3)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
urate measurement | 1 | 1 | 1 | 63.1 | |||||
optic disc area measurement | 1 | 1 | 2 | 52.7 | |||||
self reported educational attainment | 1 | 1 | 1 | 33.1 | |||||
diet measurement | 1 | 1 | 1 | 29 | |||||
neuroticism measurement | 1 | 1 | 1 | 21.5 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
urate measurement | 1 | 63.1 | |||||
optic disc area measurement | 2 | 52.7 | |||||
self reported educational attainment | 1 | 33.1 | |||||
diet measurement | 1 | 29 | |||||
neuroticism measurement | 1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | family with sequence similarity 19 member A4, C-C motif chemokine like | VGNC:10479 | 736206 | |||||
Macaque | family with sequence similarity 19 member A4, C-C motif chemokine like | 696987 | ||||||
Mouse | MGI:2444563 | 320701 | ||||||
Rat | RGD:1597443 | 689043 | ||||||
Dog | family with sequence similarity 19 member A4, C-C motif chemokine like | VGNC:40648 | 610997 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | family with sequence similarity 19 member A4, C-C motif chemokine like | |||||
Macaque | family with sequence similarity 19 member A4, C-C motif chemokine like | |||||
Mouse | ||||||
Rat | ||||||
Dog | family with sequence similarity 19 member A4, C-C motif chemokine like | |||||
Publication Statistics
PubMed Score 29.41
PubMed score by year
PubTator Score 9.73
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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