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Tdark
FAM19A3
Protein FAM19A3

Protein Summary
Description
Plays a role in the regulation of microglia polarization. This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361886
  • ENSP00000355042
  • ENSG00000184599
  • ENST00000369630
  • ENSP00000358644

Symbol
  • TAFA3
  • TAFA-3
  • FAM19A3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
gene perturbation
0.56
tissue
0.51
transcription factor binding site profile
0.48
cell line
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.32   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.32   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
FLAD1
Tbio
Family:  Enzyme
Novelty:  0.02230368
p_int:  0.999997957
p_ni:  0.000002043
Data Source:  BioPlex
DHPS
Tchem
Family:  Enzyme
Novelty:  0.00776893
p_int:  0.999986834
p_ni:  0.000013166
Data Source:  BioPlex
FUOM
Tbio
Family:  Enzyme
Novelty:  0.0562349
p_int:  0.999959307
p_wrong:  0.000040693
Data Source:  BioPlex
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
p_int:  0.999951786
p_ni:  0.000048214
Data Source:  BioPlex
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.999903579
p_ni:  0.000096421
Data Source:  BioPlex
THNSL1
Tdark
Family:  Enzyme
Novelty:  1.98275016
p_int:  0.999865866
p_ni:  0.000134133
Data Source:  BioPlex
JMJD4
Tbio
Novelty:  0.09951585
p_int:  0.999664555
p_ni:  0.000335433
p_wrong:  1.2e-8
Data Source:  BioPlex
PRMT7
Tchem
Family:  Epigenetic
Novelty:  0.02310897
p_int:  0.99962315
p_ni:  0.000101859
p_wrong:  0.000274991
Data Source:  BioPlex
FAAP100
Tdark
Novelty:  0.1698504
p_int:  0.999473096
p_ni:  0.000526904
Data Source:  BioPlex
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
p_int:  0.999426743
p_ni:  0.000573257
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
5
6
8.1
96.9
creatinine measurement
2
2
2
92.5
platelet count
2
2
2
91.9
diastolic blood pressure
3
3
6
86.9
mean platelet volume
1
1
1
78.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
8.1
96.9
creatinine measurement
2
92.5
platelet count
2
91.9
diastolic blood pressure
6
86.9
mean platelet volume
1
78.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 19 member A3, C-C motif chemokine like
VGNC:10634
743913
Macaque
family with sequence similarity 19 member A3, C-C motif chemokine like
706250
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 19 member A3, C-C motif chemokine like
Macaque
family with sequence similarity 19 member A3, C-C motif chemokine like
Publication Statistics
PubMed Score 2.32
PubMed score by year
PubTator Score 0.57
PubTator score by year
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Related Publications
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PMID
Year
Title