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Tbio
FAM19A2
Protein FAM19A2

Protein Summary
Description
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000416284
  • ENSP00000393987
  • ENSG00000198673
  • ENST00000550003
  • ENSP00000449457
  • ENST00000551619
  • ENSP00000447305

Symbol
  • TAFA2
  • TAFA-2
  • FAM19A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
gene perturbation
0.76
phenotype
0.73
cell type or tissue
0.55
transcription factor
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.88   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.88   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
LIFR
Tbio
Novelty:  0.00514085
p_int:  0.999999705
p_ni:  2.94e-7
p_wrong:  1e-9
Data Source:  BioPlex
CNTNAP1
Tbio
Novelty:  0.00618741
p_int:  0.999994718
p_ni:  0.000005282
Data Source:  BioPlex
LEPR
Tclin
Novelty:  0.00070587
p_int:  0.999963061
p_ni:  0.000036927
p_wrong:  1.3e-8
Data Source:  BioPlex
CPE
Tbio
Family:  Enzyme
Novelty:  0.00197792
p_int:  0.999887694
p_ni:  0.000112298
p_wrong:  7e-9
Data Source:  BioPlex
PAM
Tchem
Family:  Enzyme
Novelty:  0.00378397
p_int:  0.999558303
p_ni:  0.000441697
Data Source:  BioPlex
M6PR
Tbio
Novelty:  0.00210407
p_int:  0.99882542
p_ni:  0.00117458
Data Source:  BioPlex
MRC2
Tbio
Novelty:  0.01100289
p_int:  0.998495485
p_ni:  0.001504515
Data Source:  BioPlex
FREM2
Tbio
Novelty:  0.03382033
p_int:  0.99755289
p_ni:  0.00244711
Data Source:  BioPlex
TMEM67
Tbio
Novelty:  0.02573267
p_int:  0.997345581
p_ni:  0.002654412
p_wrong:  7e-9
Data Source:  BioPlex
TGFBR3
Tbio
Novelty:  0.0077307
p_int:  0.996251968
p_ni:  0.003617152
p_wrong:  0.00013088
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
78.2
self reported educational attainment
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
78.2
self reported educational attainment
1
27.3
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
family with sequence similarity 19 member A2, C-C motif chemokine like
716656
Mouse
MGI:2143691
268354
Rat
RGD:1589429
680647
Dog
family with sequence similarity 19 member A2, C-C motif chemokine like
VGNC:40647
607990
Horse
family with sequence similarity 19 member A2, C-C motif chemokine like
VGNC:17842
100629297
Species
Name
OMA
EggNOG
Inparanoid
Macaque
family with sequence similarity 19 member A2, C-C motif chemokine like
Mouse
Rat
Dog
family with sequence similarity 19 member A2, C-C motif chemokine like
Horse
family with sequence similarity 19 member A2, C-C motif chemokine like
Publication Statistics
PubMed Score 6.88
PubMed score by year
PubTator Score 1.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title