Protein Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
- ENST00000416284
- ENSP00000393987
- ENSG00000198673
- ENST00000550003
- ENSP00000449457
- ENST00000551619
- ENSP00000447305
- TAFA2
- TAFA-2
- FAM19A2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.86 | ||
gene perturbation | 0.76 | ||
phenotype | 0.73 | ||
cell type or tissue | 0.55 | ||
transcription factor | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.88 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 29 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.88 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 29 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (91)
LEPR
Novelty: 0.00070587
p_int: 0.999963061
p_ni: 0.000036927
p_wrong: 1.3e-8
Data Source: BioPlex
CPE
Family: Enzyme
Novelty: 0.00197792
p_int: 0.999887694
p_ni: 0.000112298
p_wrong: 7e-9
Data Source: BioPlex
PAM
Family: Enzyme
Novelty: 0.00378397
p_int: 0.999558303
p_ni: 0.000441697
Data Source: BioPlex
TMEM67
Novelty: 0.02573267
p_int: 0.997345581
p_ni: 0.002654412
p_wrong: 7e-9
Data Source: BioPlex
TGFBR3
Novelty: 0.0077307
p_int: 0.996251968
p_ni: 0.003617152
p_wrong: 0.00013088
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (1)
Components (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet crit | 2 | 2 | 2 | 78.2 | |||||
self reported educational attainment | 1 | 1 | 1 | 27.3 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet crit | 2 | 78.2 | |||||
self reported educational attainment | 1 | 27.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | family with sequence similarity 19 member A2, C-C motif chemokine like | 716656 | ||||||
Mouse | MGI:2143691 | 268354 | ||||||
Rat | RGD:1589429 | 680647 | ||||||
Dog | family with sequence similarity 19 member A2, C-C motif chemokine like | VGNC:40647 | 607990 | |||||
Horse | family with sequence similarity 19 member A2, C-C motif chemokine like | VGNC:17842 | 100629297 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | family with sequence similarity 19 member A2, C-C motif chemokine like | |||||
Mouse | ||||||
Rat | ||||||
Dog | family with sequence similarity 19 member A2, C-C motif chemokine like | |||||
Horse | family with sequence similarity 19 member A2, C-C motif chemokine like | |||||
Publication Statistics
PubMed Score 6.88
PubMed score by year
PubTator Score 1.97
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
|---|