Protein Summary
This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
- ENST00000350210
- ENSP00000307128
- ENSG00000160767
- ENST00000361361
- ENSP00000354958
- ENST00000368368
- ENSP00000357352
- ENST00000572488
- ENSP00000458501
- ENSG00000262666
- ENST00000574749
- ENSP00000460960
- ENST00000575430
- ENSP00000461152
- C1orf2
- COTE1
- COTE1
- C1orf2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.85 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.65 | ||
histone modification site profile | 0.59 | ||
tissue sample | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.19 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 75 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.19 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 75 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (89)
WWOX
Family: Enzyme
Novelty: 0.00335243
p_int: 0.999999989
p_ni: 1.1e-8
Score: 0.533
Data Source: BioPlex,STRINGDB
HECW1
Family: Enzyme
Novelty: 0.15200354
p_int: 0.999999953
p_ni: 1.2e-8
p_wrong: 3.4e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
HECW2
Family: Enzyme
Novelty: 0.07194044
p_int: 0.999999896
p_ni: 9.4e-8
p_wrong: 1e-8
Score: 0.313
Data Source: BioPlex,STRINGDB
NEDD4L
Family: Enzyme
Novelty: 0.00250567
p_int: 0.999997253
p_ni: 0.000002747
Score: 0.192
Data Source: BioPlex,STRINGDB
CYHR1
Novelty: 0.04771996
p_int: 0.999996392
p_ni: 0.000002859
p_wrong: 7.49e-7
Data Source: BioPlex
NEDD4
Family: Enzyme
Novelty: 0.00281725
p_int: 0.99998787
p_ni: 0.00001213
Score: 0.22
Data Source: BioPlex,STRINGDB
RNF111
Family: Enzyme
Novelty: 0.03059486
p_int: 0.999957805
p_ni: 0.000021491
p_wrong: 0.000020704
Data Source: BioPlex
SMO
Family: GPCR
Novelty: 0.03235855
p_int: 0.99995352
p_ni: 0.000046396
p_wrong: 8.4e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
ABCD4
Family: Transporter
Novelty: 0.04096359
p_int: 0.999935215
p_ni: 0.00006478
p_wrong: 5e-9
Data Source: BioPlex
ANKRD13D
Novelty: 2.14380936
p_int: 0.999845877
p_ni: 0.000154123
Score: 0.539
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (2)
Functions (1)
Components (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (86)
Items per page:
1 – 5 of 86
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
urate measurement | 6 | 5 | 9 | 98.3 | ||||||
urate measurement | 6 | 5 | 9 | 98.3 | ||||||
serum urea measurement | 2 | 3 | 3 | 95.4 | ||||||
serum urea measurement | 2 | 3 | 3 | 95.4 | ||||||
serum gamma-glutamyl transferase measurement | 2 | 3 | 2 | 3.7 | 94.6 | |||||
Items per page:
1 – 5 of 86
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 9 | 98.3 | |||||
urate measurement | 9 | 98.3 | |||||
serum urea measurement | 3 | 95.4 | |||||
serum urea measurement | 3 | 95.4 | |||||
serum gamma-glutamyl transferase measurement | 2 | 3.7 | 94.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | family with sequence similarity 189 member B | VGNC:10625 | 457362 | |||||
Macaque | family with sequence similarity 189 member B | 719116 | ||||||
Mouse | MGI:1915771 | 68521 | ||||||
Rat | RGD:1306107 | 310640 | ||||||
Dog | family with sequence similarity 189 member B | VGNC:40639 | 490428 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | family with sequence similarity 189 member B | |||||
Macaque | family with sequence similarity 189 member B | |||||
Mouse | ||||||
Rat | ||||||
Dog | family with sequence similarity 189 member B | |||||
Publication Statistics
PubMed Score 6.19
PubMed score by year
PubTator Score 5.08
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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