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Tbio
FAM189B
Protein FAM189B

Protein Summary
Description
This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350210
  • ENSP00000307128
  • ENSG00000160767
  • ENST00000361361
  • ENSP00000354958
  • ENST00000368368
  • ENSP00000357352
  • ENST00000572488
  • ENSP00000458501
  • ENSG00000262666
  • ENST00000574749
  • ENSP00000460960
  • ENST00000575430
  • ENSP00000461152

Symbol
  • C1orf2
  • COTE1
  • COTE1
  • C1orf2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.85
kinase perturbation
0.81
transcription factor binding site profile
0.65
histone modification site profile
0.59
tissue sample
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.27   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.27   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0