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Tdark
FAM171B
Protein FAM171B

Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.41   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.41   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
FAM171A1
Tdark
Novelty:  0.69704346
p_int:  0.999999834
p_ni:  1.59e-7
p_wrong:  7e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
FAM171A2
Tdark
Novelty:  1.18763693
p_int:  0.999980057
p_ni:  0.000019941
p_wrong:  2e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
C4A
Tbio
Novelty:  0.00062793
p_int:  0.998677987
p_ni:  0.001322012
Score:  0.161
Data Source:  BioPlex,STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.988143336
p_ni:  0.009902182
p_wrong:  0.001954482
Score:  0.151
Data Source:  BioPlex,STRINGDB
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
p_int:  0.961732225
p_ni:  0.038267775
p_wrong:  1e-9
Data Source:  BioPlex
STX6
Tbio
Novelty:  0.01494028
p_int:  0.958392407
p_ni:  0.041387183
p_wrong:  0.00022041
Data Source:  BioPlex
PHKG2
Tchem
Family:  Kinase
Novelty:  0.064884
p_int:  0.944153929
p_ni:  0.000004173
p_wrong:  0.055841898
Score:  0.179
Data Source:  BioPlex,STRINGDB
MFAP3
Tdark
Novelty:  0.55512255
p_int:  0.915420456
p_ni:  0.08457727
p_wrong:  0.000002274
Data Source:  BioPlex
MIB1
Tbio
Family:  Enzyme
Novelty:  0.03288048
p_int:  0.863792393
p_ni:  0.136207607
Score:  0.187
Data Source:  BioPlex,STRINGDB
TMEM59L
Tbio
Novelty:  0.22745646
Score:  0.839
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
2
2
76.1
FEV/FEC ratio
1
1
1
63.4
1
1
0
1.1
35
BMI-adjusted waist circumference
1
1
1
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
76.1
FEV/FEC ratio
1
63.4
0
1.1
35
BMI-adjusted waist circumference
1
0.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 171 member B
VGNC:1946
459808
Macaque
family with sequence similarity 171 member B
712442
Mouse
MGI:2444579
241520
Rat
RGD:1562526
499821
Dog
family with sequence similarity 171 member B
VGNC:40624
611224
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 171 member B
Macaque
family with sequence similarity 171 member B
Mouse
Rat
Dog
family with sequence similarity 171 member B
Publication Statistics
PubMed Score 3.41
PubMed score by year
PubTator Score 0.09
PubTator score by year
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Related Publications
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PMID
Year
Title