You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
FAM170A
Protein FAM170A

Protein Summary
Description
Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335286
  • ENSP00000334285
  • ENSG00000164334
  • ENST00000379555
  • ENSP00000368873
  • ENST00000515256
  • ENSP00000422684
  • ENST00000613773
  • ENSP00000482552
  • ENST00000620555
  • ENSP00000483075

Symbol
  • ZNFD
  • ZNFD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.56
transcription factor
0.53
biological process
0.51
gene perturbation
0.47
tissue sample
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.14   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.14   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
CSNK1A1L
Tdark
Family:  Kinase
Novelty:  0.72324265
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.388
Data Source:  BioPlex,STRINGDB
CSNK1A1
Tchem
Family:  Kinase
Novelty:  0.00636472
p_int:  0.999999971
p_ni:  2.9e-8
Score:  0.311
Data Source:  BioPlex,STRINGDB
ZNF358
Tdark
Family:  TF
Novelty:  0.77495044
p_int:  0.999983481
p_ni:  0.000006419
p_wrong:  0.000010101
Score:  0.228
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999845865
p_ni:  0.000154135
Score:  0.581
Data Source:  BioPlex,STRINGDB
ESS2
Tbio
Novelty:  0.00163665
p_int:  0.999410785
p_ni:  0.000589215
Data Source:  BioPlex
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999058205
p_ni:  0.000941732
p_wrong:  6.3e-8
Data Source:  BioPlex
QSER1
Tdark
Novelty:  0.62017582
p_int:  0.991205604
p_ni:  0.002862659
p_wrong:  0.005931737
Score:  0.209
Data Source:  BioPlex,STRINGDB
MIER1
Tbio
Novelty:  0.00357772
p_int:  0.990535577
p_ni:  0.009464423
Score:  0.209
Data Source:  BioPlex,STRINGDB
USP7
Tchem
Family:  Enzyme
Novelty:  0.00412878
p_int:  0.988681886
p_ni:  0.011318114
Data Source:  BioPlex
SPC25
Tbio
Novelty:  0.26354244
p_int:  0.985956918
p_ni:  0.013984512
p_wrong:  0.00005857
Score:  0.527
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
2
2
59.4
waist-hip ratio
1
2
2
59.4
BMI-adjusted hip circumference
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
59.4
waist-hip ratio
2
59.4
BMI-adjusted hip circumference
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 170 member A
VGNC:3989
741273
Macaque
family with sequence similarity 170 member A
701046
Mouse
MGI:2684939
225497
Rat
RGD:1565393
498864
Horse
family with sequence similarity 170 member A
VGNC:17822
100073129
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 170 member A
Macaque
family with sequence similarity 170 member A
Mouse
Rat
Horse
family with sequence similarity 170 member A
Publication Statistics
PubMed Score 14.14
PubMed score by year
PubTator Score 1.00
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title