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Tdark
FAM169A
Soluble lamin-associated protein of 75 kDa

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389156
  • ENSP00000373808
  • ENSG00000198780
  • ENST00000510609
  • ENSP00000423905
  • ENST00000514215
  • ENSP00000425319

Symbol
  • KIAA0888
  • SLAP75
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.73
gene perturbation
0.72
cell type or tissue
0.59
small molecule perturbation
0.57
tissue sample
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.19   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.19   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (13)
INHBE
Tbio
Novelty:  0.07526145
p_int:  0.956430752
p_ni:  1.7e-8
p_wrong:  0.043569231
Score:  0.369
Data Source:  BioPlex,STRINGDB
ZNF407
Tbio
Family:  TF
Novelty:  0.16936176
Score:  0.687
Data Source:  STRINGDB
AFG1L
Tbio
Novelty:  0.0034716
Score:  0.604
Data Source:  STRINGDB
TP53RK
Tbio
Family:  Kinase
Novelty:  0.04302252
Score:  0.56
Data Source:  STRINGDB
PLPP7
Tdark
Family:  Enzyme
Novelty:  0.28747179
Score:  0.535
Data Source:  STRINGDB
CXorf56
Tdark
Novelty:  0.39137617
Score:  0.53
Data Source:  STRINGDB
ARPIN
Tbio
Novelty:  0.18393143
Score:  0.513
Data Source:  STRINGDB
KCNK9
Tclin
Family:  IC
Novelty:  0.00587016
Score:  0.496
Data Source:  STRINGDB
METAP1
Tchem
Family:  Enzyme
Novelty:  0.01816253
Score:  0.493
Data Source:  STRINGDB
CUSTOS
Tdark
Novelty:  0.50471779
Score:  0.491
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
3
3
46.9
total cholesterol measurement
1
1
1
9.3
apolipoprotein B measurement
1
1
1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
46.9
total cholesterol measurement
1
9.3
apolipoprotein B measurement
1
2.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 169 member A
VGNC:3988
461805
Mouse
MGI:2444268
320557
Rat
RGD:1590893
310013
Dog
family with sequence similarity 169 member A
VGNC:40621
487248
Horse
family with sequence similarity 169 member A [Source:HGNC Symbol;Acc:HGNC:29138]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 169 member A
Mouse
Rat
Dog
family with sequence similarity 169 member A
Horse
family with sequence similarity 169 member A [Source:HGNC Symbol;Acc:HGNC:29138]
Publication Statistics
PubMed Score 2.19
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
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PMID
Year
Title