Protein Summary
In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.
- ENST00000064778
- ENSP00000064778
- ENSG00000054965
- ENST00000356467
- ENSP00000348852
- ENST00000450446
- ENSP00000390501
- KIAA0280
- TCRP1
- TCRP1
- KIAA0280
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.91 | ||
kinase perturbation | 0.88 | ||
histone modification site profile | 0.85 | ||
virus perturbation | 0.68 | ||
tissue sample | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.61 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 39 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.61 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 39 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (24)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (1)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 1 | 1 | 75 | |||||
forced expiratory volume | 1 | 1 | 1 | 61 | |||||
smoking status measurement | 2 | 2 | 2 | 58.9 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 40.7 | |||||
platelet count | 1 | 1 | 1 | 36.9 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 75 | |||||
forced expiratory volume | 1 | 61 | |||||
smoking status measurement | 2 | 58.9 | |||||
mean corpuscular hemoglobin concentration | 1 | 40.7 | |||||
platelet count | 1 | 36.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | family with sequence similarity 168 member A | 718182 | ||||||
Mouse | MGI:2442372 | 319604 | ||||||
Rat | RGD:1308929 | 361614 | ||||||
Dog | family with sequence similarity 168 member A | VGNC:40619 | 609451 | |||||
Horse | family with sequence similarity 168 member A | VGNC:17821 | 100052387 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | family with sequence similarity 168 member A | |||||
Mouse | ||||||
Rat | ||||||
Dog | family with sequence similarity 168 member A | |||||
Horse | family with sequence similarity 168 member A | |||||
Publication Statistics
PubMed Score 15.61
PubMed score by year
PubTator Score 8.63
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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