Protein Summary
Involved in ciliogenesis. This gene belongs to the FAM161 family. It is expressed mainly in the retina. Mouse studies suggested that this gene is involved in development of retinal progenitors during embryogenesis, and that its activity is restricted to mature photoreceptors after birth. Mutations in this gene cause autosomal recessive retinitis pigmentosa-28. Alternatively spliced transcript variants have been identified.[provided by RefSeq, Jan 2011]
- ENST00000404929
- ENSP00000385158
- ENSG00000170264
- ENST00000405894
- ENSP00000385893
- RP28
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.98 | ||
histone modification site profile | 0.77 | ||
cellular component | 0.71 | ||
transcription factor binding site profile | 0.65 | ||
microRNA | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.68 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 73 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.68 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 73 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (104)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (2)
Components (8)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
amino acid measurement | 1 | 1 | 2 | 28.1 | |||||
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1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
amino acid measurement | 2 | 28.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | FAM161A, centrosomal protein | VGNC:2932 | 459265 | |||||
Macaque | family with sequence similarity 161 member A | 719626 | ||||||
Mouse | MGI:1921123 | 73873 | ||||||
Rat | RGD:1304999 | 289833 | ||||||
Dog | FAM161A, centrosomal protein | VGNC:40610 | 100855510 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | FAM161A, centrosomal protein | |||||
Macaque | family with sequence similarity 161 member A | |||||
Mouse | ||||||
Rat | ||||||
Dog | FAM161A, centrosomal protein | |||||
Publication Statistics
PubMed Score 20.68
PubMed score by year
PubTator Score 14.56
PubTator score by year
Related Publications
Text Mined References (25)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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