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Tbio
FAM160A2
FTS and Hook-interacting protein

Protein Summary
Description
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). The protein encoded by this gene is part of the FTS/Hook/FHIP (FHF) complex, which can interact with members of the homotypic vesicular protein sorting (HOPS) complex. This interaction suggests that the encoded protein is involved in vesicle trafficking. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265978
  • ENSP00000265978
  • ENSG00000051009
  • ENST00000449352
  • ENSP00000416918

Symbol
  • C11orf56
  • KIAA1759
  • FHIP
  • C11orf56
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
histone modification site profile
0.86
kinase perturbation
0.84
tissue sample
0.7
transcription factor binding site profile
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.73   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.73   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
HOOK3
Tbio
Novelty:  0.0553474
p_int:  0.999999996
p_ni:  1e-9
p_wrong:  3e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
AKTIP
Tbio
Novelty:  0.00315951
p_int:  0.999999908
p_ni:  6e-9
p_wrong:  8.5e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.999634903
p_ni:  0.00002599
p_wrong:  0.000339107
Score:  0.817
Data Source:  BioPlex,STRINGDB
HOOK1
Tbio
Novelty:  0.04136856
Score:  0.975
Data Source:  STRINGDB
HOOK2
Tbio
Novelty:  0.03559628
Score:  0.953
Data Source:  STRINGDB
C12orf4
Tdark
Novelty:  0.35695485
Score:  0.61
Data Source:  STRINGDB
NINL
Tbio
Novelty:  0.00726815
Score:  0.571
Data Source:  STRINGDB
RAB3IL1
Tbio
Novelty:  0.0167537
Score:  0.545
Data Source:  STRINGDB
BICDL2
Tdark
Novelty:  2.61148707
Score:  0.518
Data Source:  STRINGDB
KIF1C
Tbio
Novelty:  0.03162961
Score:  0.501
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
GOC
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
38.8
body mass index
1
1
1
29
mathematical ability
3
1
3
9.5
1
1
0
1
3.5
multisite chronic pain
1
1
1
2.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
38.8
body mass index
1
29
mathematical ability
3
9.5
0
1
3.5
multisite chronic pain
1
2.5
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 160 member A2
VGNC:3274
450987
Macaque
family with sequence similarity 160 member A2
711641
Mouse
MGI:1921599
74349
Rat
RGD:1359585
293343
Dog
family with sequence similarity 160 member A2
VGNC:40607
485332
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 160 member A2
Macaque
family with sequence similarity 160 member A2
Mouse
Rat
Dog
family with sequence similarity 160 member A2
Publication Statistics
PubMed Score 1.73
PubMed score by year
PubTator Score 4.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title