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Tdark
FAM136A
Protein FAM136A

Protein Summary
Description
This gene encodes a mitochondrially localized protein that is highly conserved across species. The gene is expressed in a variety of tissues including human lymphoblast cells and rat neurosensorial epithelium of the cristaampullaris. A mutation in this gene has been associated with familial Meniere's disease, a chronic disorder of the inner ear. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000037869
  • ENSP00000037869
  • ENSG00000035141
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.82
transcription factor binding site profile
0.77
tissue sample
0.67
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.07   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.07   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
RBFOX3
Tbio
Novelty:  0.00038317
p_int:  0.999997977
p_ni:  0.000002023
Score:  0.188
Data Source:  BioPlex,STRINGDB
PIK3C2A
Tchem
Family:  Kinase
Novelty:  0.0002219
p_int:  0.999996979
p_ni:  0.000003021
Data Source:  BioPlex
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.9999956
p_ni:  0.0000044
Score:  0.193
Data Source:  BioPlex,STRINGDB
CDYL
Tchem
Family:  Epigenetic
Novelty:  0.03367841
p_int:  0.999993416
p_ni:  0.000006584
Score:  0.16
Data Source:  BioPlex,STRINGDB
N4BP2
Tbio
Novelty:  0.12823967
p_int:  0.999989232
p_ni:  0.000010768
Score:  0.188
Data Source:  BioPlex,STRINGDB
ASPSCR1
Tbio
Novelty:  0.01172319
p_int:  0.999980325
p_ni:  0.000019675
Data Source:  BioPlex
RGPD8
Tdark
Novelty:  0.12397737
p_int:  0.999974792
p_ni:  0.000025208
Data Source:  BioPlex
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.99992475
p_ni:  0.00007525
Score:  0.19
Data Source:  BioPlex,STRINGDB
COX10
Tbio
Family:  Enzyme
Novelty:  0.0156235
p_int:  0.999859232
p_ni:  1.26e-7
p_wrong:  0.000140642
Score:  0.202
Data Source:  BioPlex,STRINGDB
RNASEH2A
Tbio
Family:  Enzyme
Novelty:  0.00478657
p_int:  0.999665604
p_ni:  0.000334396
Score:  0.223
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
65.3
total cholesterol measurement
2
2
2
61.8
chronotype measurement
2
1
1
1
60.5
cognitive function measurement
1
1
1
33.1
self reported educational attainment
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
65.3
total cholesterol measurement
2
61.8
chronotype measurement
1
1
60.5
cognitive function measurement
1
33.1
self reported educational attainment
1
31.4
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:1304825
297415
Horse
family with sequence similarity 136 member A
VGNC:51299
100060557
Xenopus
family with sequence similarity 136 member A
XB-GENE-943724
548941
Species
Name
OMA
EggNOG
Inparanoid
Rat
Horse
family with sequence similarity 136 member A
Xenopus
family with sequence similarity 136 member A
Publication Statistics
PubMed Score 3.07
PubMed score by year
PubTator Score 1.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title