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Tdark
FAM131B
Protein FAM131B

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409222
  • ENSP00000387147
  • ENSG00000159784
  • ENST00000409346
  • ENSP00000386984
  • ENST00000409408
  • ENSP00000387017
  • ENST00000409578
  • ENSP00000386568
  • ENST00000443739
  • ENSP00000410603

Symbol
  • KIAA0773
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
microRNA
0.76
histone modification site profile
0.63
tissue
0.59
cell line
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.58   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.58   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
p_int:  0.999983793
p_ni:  0.000016202
p_wrong:  5e-9
Score:  0.208
Data Source:  BioPlex,STRINGDB
CBWD3
Tdark
Novelty:  0.03639787
p_int:  0.999792432
p_ni:  0.000207544
p_wrong:  2.4e-8
Data Source:  BioPlex
TOP2A
Tclin
Family:  Enzyme
Novelty:  0.00122788
p_int:  0.996340577
p_ni:  0.0036594
p_wrong:  2.3e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
GNPAT
Tchem
Family:  Enzyme
Novelty:  0.01255689
p_int:  0.994921438
p_ni:  0.005078562
Data Source:  BioPlex
CDC6
Tbio
Novelty:  0.00219371
p_int:  0.992070232
p_ni:  0.007929767
p_wrong:  1e-9
Data Source:  BioPlex
UQCRH
Tbio
Novelty:  0.04494433
p_int:  0.976719324
p_ni:  0.004990333
p_wrong:  0.018290343
Data Source:  BioPlex
FAM208A
Tbio
Novelty:  0.17789689
p_int:  0.973311315
p_ni:  0.026688678
p_wrong:  7e-9
Data Source:  BioPlex
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.969142274
p_ni:  0.030721945
p_wrong:  0.000135781
Data Source:  BioPlex
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.964055744
p_ni:  0.035944256
Data Source:  BioPlex
UHRF1BP1
Tbio
Novelty:  0.1588079
p_int:  0.958509028
p_ni:  0.041490971
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Oncogenic MAPK signaling
Reactome
Signaling by BRAF and RAF fusions
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Oncogenic MAPK signaling
Signaling by BRAF and RAF fusions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
89.2
basophil count
3
1
3
85.2
basophil percentage of leukocytes
1
1
1
84.9
6
4
0
1.1
77.2
monocyte count
1
1
1
74.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
89.2
basophil count
3
85.2
basophil percentage of leukocytes
1
84.9
0
1.1
77.2
monocyte count
1
74.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 131 member B
VGNC:4345
463805
Macaque
family with sequence similarity 131 member B
706530
Mouse
MGI:1923406
76156
Rat
RGD:1560653
500102
Dog
family with sequence similarity 131 member B
VGNC:40592
608789
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 131 member B
Macaque
family with sequence similarity 131 member B
Mouse
Rat
Dog
family with sequence similarity 131 member B
Publication Statistics
PubMed Score 2.58
PubMed score by year
PubTator Score 0.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title