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Tbio
FAM122A
Protein FAM122A

Protein Summary
Description
Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394264
  • ENSP00000377807
  • ENSG00000187866

Symbol
  • C9orf42
  • C9orf42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.8
histone modification site profile
0.76
cell type or tissue
0.72
drug perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.14   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.14   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
PPP3CA
Tchem
Family:  Enzyme
Novelty:  0.00234189
p_int:  1
Score:  0.739
Data Source:  BioPlex,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.999999591
p_ni:  4.09e-7
Data Source:  BioPlex
RCAN1
Tbio
Novelty:  0.0030009
p_int:  0.999875073
p_ni:  0.000014226
p_wrong:  0.000110701
Score:  0.85
Data Source:  BioPlex,STRINGDB
FAM122B
Tdark
Novelty:  1.90668674
p_int:  0.999584399
p_ni:  0.000379569
p_wrong:  0.000036033
Score:  0.821
Data Source:  BioPlex,STRINGDB
PPP2R2C
Tbio
Family:  Enzyme
Novelty:  0.05453128
p_int:  0.998175458
p_ni:  0.001816834
p_wrong:  0.000007707
Score:  0.625
Data Source:  BioPlex,STRINGDB
PPP3R1
Tbio
Novelty:  0.00263264
p_int:  0.998014642
p_ni:  0.001981879
p_wrong:  0.000003478
Score:  0.562
Data Source:  BioPlex,STRINGDB
FHL3
Tbio
Novelty:  0.11505924
p_int:  0.98732278
p_ni:  0.01267722
Score:  0.521
Data Source:  BioPlex,STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.963517722
p_ni:  0.036342115
p_wrong:  0.000140163
Score:  0.772
Data Source:  BioPlex,STRINGDB
KLHL15
Tbio
Novelty:  0.54712519
p_int:  0.882764187
p_ni:  0.117235813
Data Source:  BioPlex
CIP2A
Tbio
Novelty:  0.00992381
Score:  0.678
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
8
6
9
11.6
98.3
creatinine measurement
5
5
6
95.4
calcium measurement
1
1
1
71.5
urate measurement
1
1
1
56.8
fibroblast growth factor 23 measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
11.6
98.3
creatinine measurement
6
95.4
calcium measurement
1
71.5
urate measurement
1
56.8
fibroblast growth factor 23 measurement
1
54.4
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915284
68034
Rat
RGD:1310316
309420
Dog
family with sequence similarity 122A
VGNC:40586
609077
Horse
family with sequence similarity 122A
VGNC:17793
100057045
Cow
family with sequence similarity 122A
VGNC:28722
539712
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
family with sequence similarity 122A
Horse
family with sequence similarity 122A
Cow
family with sequence similarity 122A
Publication Statistics
PubMed Score 5.14
PubMed score by year
PubTator Score 2.30
PubTator score by year
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Related Publications
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PMID
Year
Title