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Tbio
FAM120A
Constitutive coactivator of PPAR-gamma-like protein 1

Protein Summary
Description
May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277165
  • ENSP00000277165
  • ENSG00000048828
  • ENST00000375389
  • ENSP00000364538

Symbol
  • C9orf10
  • KIAA0183
  • OSSA
  • OSSA
  • C9orf10
  • HBVPTPAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
interacting protein
0.95
disease perturbation
0.87
PubMedID
0.71
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.03   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.03   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
IFI30
Tbio
Family:  Enzyme
Novelty:  0.00939681
p_int:  0.999120834
p_ni:  0.000879166
Data Source:  BioPlex
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.998025289
p_ni:  0.001974711
Score:  0.218
Data Source:  BioPlex,STRINGDB
PRMT8
Tchem
Family:  Epigenetic
Novelty:  0.04213384
p_int:  0.995180858
p_ni:  0.004819142
Score:  0.516
Data Source:  BioPlex,STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
p_int:  0.988852077
p_ni:  0.011147923
Score:  0.525
Data Source:  BioPlex,STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.973731938
p_ni:  0.026268062
Data Source:  BioPlex
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.970033493
p_ni:  0.029966507
Data Source:  BioPlex
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
p_int:  0.962536454
p_ni:  0.037463545
Data Source:  BioPlex
GGPS1
Tchem
Family:  Enzyme
Novelty:  0.00292258
p_int:  0.957544728
p_ni:  0.042455272
Score:  0.193
Data Source:  BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty:  0.01102619
p_int:  0.915269911
p_ni:  0.084730089
Data Source:  BioPlex
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.902796636
p_ni:  0.097203364
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
6
88.5
self reported educational attainment
3
4
4
88
comparative body size at age 10, self-reported
1
1
1
77.7
loneliness measurement
4
3
3
6.4
75.2
3
3
2
5.7
72.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
6
88.5
self reported educational attainment
4
88
comparative body size at age 10, self-reported
1
77.7
loneliness measurement
3
6.4
75.2
2
5.7
72.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 120A
VGNC:4688
107966257
Macaque
family with sequence similarity 120A
717459
Mouse
MGI:2446163
218236
Rat
RGD:1306643
291019
Dog
family with sequence similarity 120A
VGNC:53715
610549
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 120A
Macaque
family with sequence similarity 120A
Mouse
Rat
Dog
family with sequence similarity 120A
Publication Statistics
PubMed Score 11.03
PubMed score by year
PubTator Score 6.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title