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Tbio
FAM111A
Protein FAM111A

Protein Summary
Description
Chromatin-associated protein required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis (PubMed:24561620). May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction (PubMed:23093934). The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA). Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS, also known as Gracile Bone Dysplasia), both characterized by short stature, hypoparathyroidism, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361723
  • ENSP00000355264
  • ENSG00000166801
  • ENST00000420244
  • ENSP00000406683
  • ENST00000528737
  • ENSP00000434435
  • ENST00000531147
  • ENSP00000431631
  • ENST00000533703
  • ENSP00000433154

Symbol
  • KIAA1895
  • KCS2
  • GCLEB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
transcription factor
0.72
tissue sample
0.7
phenotype
0.66
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.71   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.71   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
TP53
Tchem
Family:  TF
Novelty:  0.00001907
p_int:  0.952013352
p_ni:  0.047986648
Score:  0.403
Data Source:  BioPlex,STRINGDB
TBCE
Tbio
Novelty:  0.01058281
Score:  0.907
Data Source:  STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.706
Data Source:  STRINGDB
OR6T1
Tdark
Family:  oGPCR
Novelty:  35
Score:  0.559
Data Source:  STRINGDB
HEATR9
Tdark
Novelty:  0.71415315
Score:  0.511
Data Source:  STRINGDB
FAM221A
Tdark
Novelty:  1.40181414
Score:  0.491
Data Source:  STRINGDB
KPNA2
Tbio
Novelty:  0.00506958
Score:  0.483
Data Source:  STRINGDB
C17orf78
Tdark
Novelty:  4.29271752
Score:  0.462
Data Source:  STRINGDB
NKAIN4
Tdark
Family:  Enzyme
Novelty:  1.65380282
Score:  0.459
Data Source:  STRINGDB
AMZ1
Tdark
Family:  Enzyme
Novelty:  0.246305
Score:  0.425
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
66.8
mathematical ability
2
1
2
7.1
sex hormone-binding globulin measurement
1
1
1
4.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
66.8
mathematical ability
2
7.1
sex hormone-binding globulin measurement
1
4.5
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 111 member A
VGNC:53063
451209
Macaque
family with sequence similarity 111 member A
701070
Mouse
MGI:1915508
107373
Rat
RGD:1560913
499322
Dog
family with sequence similarity 111 member A
VGNC:40578
609888
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 111 member A
Macaque
family with sequence similarity 111 member A
Mouse
Rat
Dog
family with sequence similarity 111 member A
Publication Statistics
PubMed Score 19.71
PubMed score by year
PubTator Score 7.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title