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Tdark
FAM104A
Protein FAM104A

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000403627
  • ENSP00000384648
  • ENSG00000133193
  • ENST00000405159
  • ENSP00000384832
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
histone modification site profile
0.8
transcription factor binding site profile
0.8
cellular component
0.73
microRNA
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.14   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 10   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.14   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (14)
UBXN2B
Tbio
Novelty:  0.67291382
p_int:  0.999997743
p_ni:  1e-8
p_wrong:  0.000002247
Score:  0.822
Data Source:  BioPlex,STRINGDB
UBXN6
Tbio
Novelty:  0.08383376
p_int:  0.99996971
p_ni:  1.9e-8
p_wrong:  0.000030271
Score:  0.847
Data Source:  BioPlex,STRINGDB
VCP
Tchem
Family:  Enzyme
Novelty:  0.00103317
p_int:  0.994359871
p_ni:  0.000001011
p_wrong:  0.005639117
Score:  0.852
Data Source:  BioPlex,STRINGDB
POLA2
Tbio
Family:  Enzyme
Novelty:  0.07371844
Score:  0.702
Data Source:  STRINGDB
LAMC3
Tbio
Novelty:  0.02221768
Score:  0.695
Data Source:  STRINGDB
KCTD6
Tbio
Novelty:  0.43478298
Score:  0.588
Data Source:  STRINGDB
APIP
Tbio
Family:  Enzyme
Novelty:  0.04661109
Score:  0.54
Data Source:  STRINGDB
O96033
Tbio
Family:  Enzyme
Novelty:  0.04174383
Score:  0.478
Data Source:  STRINGDB
O96007
Tbio
Family:  Enzyme
Novelty:  0.04174383
Score:  0.478
Data Source:  STRINGDB
IKZF4
Tbio
Family:  TF
Novelty:  0.10806913
Score:  0.471
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
79.2
mean reticulocyte volume
1
1
1
74.6
mean corpuscular volume
1
1
1
71.9
mean corpuscular hemoglobin concentration
1
1
1
64.9
reticulocyte count
2
2
2
57.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
79.2
mean reticulocyte volume
1
74.6
mean corpuscular volume
1
71.9
mean corpuscular hemoglobin concentration
1
64.9
reticulocyte count
2
57.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
family with sequence similarity 104 member A
695865
Mouse
MGI:106351
28081
Rat
RGD:1563409
619573
Dog
family with sequence similarity 104 member A
475906
Horse
family with sequence similarity 104 member A
100052690
Species
Name
OMA
EggNOG
Inparanoid
Macaque
family with sequence similarity 104 member A
Mouse
Rat
Dog
family with sequence similarity 104 member A
Horse
family with sequence similarity 104 member A
Publication Statistics
PubMed Score 1.14
PubMed score by year
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Related Publications
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0 of 0
PMID
Year
Title