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Tdark
FAHD2B
Fumarylacetoacetate hydrolase domain-containing protein 2B

Protein Summary
Description
May have hydrolase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272610
  • ENSP00000272610
  • ENSG00000144199
  • ENST00000414820
  • ENSP00000410470
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.53
tissue
0.53
tissue sample
0.52
cell line
0.49
kinase perturbation
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.85   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.85   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
FAHD2A
Tdark
Family:  Enzyme
Novelty:  0.68981789
p_int:  0.999999997
p_ni:  3e-9
Score:  0.452
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.959792141
p_ni:  0.040207851
p_wrong:  8e-9
Score:  0.194
Data Source:  BioPlex,STRINGDB
ANKRD36
Tdark
Novelty:  0.48979566
Score:  0.709
Data Source:  STRINGDB
FAM178B
Tdark
Novelty:  3.72734051
Score:  0.704
Data Source:  STRINGDB
ANKRD39
Tdark
Novelty:  8.68843298
Score:  0.676
Data Source:  STRINGDB
ITPRIPL1
Tdark
Novelty:  3.09953366
Score:  0.671
Data Source:  STRINGDB
CNNM3
Tbio
Novelty:  0.13988333
Score:  0.659
Data Source:  STRINGDB
FER1L5
Tdark
Novelty:  0.33775129
Score:  0.587
Data Source:  STRINGDB
LMAN2L
Tbio
Novelty:  0.04364985
Score:  0.585
Data Source:  STRINGDB
VWA3B
Tdark
Novelty:  0.75658049
Score:  0.565
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
1
1
59.5
cortical thickness
1
1
0
10
18.8
brain measurement
1
1
0
7.1
8.2
cortical surface area measurement
1
1
0
6.7
5.8
calcium measurement
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
59.5
cortical thickness
0
10
18.8
brain measurement
0
7.1
8.2
cortical surface area measurement
0
6.7
5.8
calcium measurement
1
4.3
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
fumarylacetoacetate hydrolase domain containing 2A
706967
Mouse
MGI:1915376
68126
Rat
RGD:1563674
296131
Dog
fumarylacetoacetate hydrolase domain-containing protein 2A
100856034
Cow
fumarylacetoacetate hydrolase domain containing 2A
404123
Species
Name
OMA
EggNOG
Inparanoid
Macaque
fumarylacetoacetate hydrolase domain containing 2A
Mouse
Rat
Dog
fumarylacetoacetate hydrolase domain-containing protein 2A
Cow
fumarylacetoacetate hydrolase domain containing 2A
Publication Statistics
PubMed Score 0.85
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
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PMID
Year
Title