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Tchem
FADS1
Acyl-CoA (8-3)-desaturase

Protein Summary
Description
Isoform 1: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (PubMed:10601301, PubMed:10769175). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain este ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433932
  • ENSP00000405087
  • ENSG00000149485
  • ENST00000542506
  • ENSP00000441403

Symbol
  • FADSD5
  • D5D
  • TU12
  • FADS6
  • FADSD5
  • LLCDL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
trait
1
transcription factor perturbation
1
disease
0.9
transcription factor binding site profile
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 667.3   (req: < 5)
Gene RIFs: 112   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 667.3   (req: >= 5)
Gene RIFs: 112   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 38
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (38)
CHEMBL4084502
Rendered image for CHEMBL4084502
CHEMBL4064555
Rendered image for CHEMBL4064555
CHEMBL4439992
Rendered image for CHEMBL4439992
CHEMBL4102458
Rendered image for CHEMBL4102458
CHEMBL4060775
Rendered image for CHEMBL4060775
CHEMBL4070383
Rendered image for CHEMBL4070383
Protein-Protein Interactions (137)
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.999586521
p_ni:  0.000413477
p_wrong:  2e-9
Data Source:  BioPlex
TACR1
Tclin
Family:  GPCR
Novelty:  0.00062762
p_int:  0.999142144
p_ni:  0.000856814
p_wrong:  0.000001041
Score:  0.208
Data Source:  BioPlex,STRINGDB
SIRT2
Tchem
Family:  Epigenetic
Novelty:  0.00093962
p_int:  0.997448879
p_ni:  0.002551104
p_wrong:  1.7e-8
Score:  0.209
Data Source:  BioPlex,STRINGDB
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.993772447
p_ni:  0.00622684
p_wrong:  7.13e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.984031327
p_ni:  0.015951653
p_wrong:  0.00001702
Data Source:  BioPlex
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.98363128
p_ni:  0.016368672
p_wrong:  4.8e-8
Data Source:  BioPlex
PTH1R
Tclin
Family:  GPCR
Novelty:  0.00413989
p_int:  0.982677581
p_ni:  0.017321354
p_wrong:  0.000001065
Data Source:  BioPlex
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
p_int:  0.979974174
p_ni:  0.019078089
p_wrong:  0.000947737
Data Source:  BioPlex
TMEM63C
Tdark
Family:  IC
Novelty:  0.02849254
p_int:  0.979273953
p_ni:  0.019695935
p_wrong:  0.001030112
Data Source:  BioPlex
VSTM1
Tbio
Novelty:  0.08630646
p_int:  0.977844969
p_ni:  0.020847349
p_wrong:  0.001307682
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (53)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Linoleic acid (LA) metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Linoleic acid (LA) metabolism
Metabolism
Metabolism of lipids
PPARA activates gene expression
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (124)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
5
17
43
99.9
docosapentaenoic acid measurement
2
13
16
99.8
high density lipoprotein cholesterol measurement
15
23
40
1.9
99.8
serum metabolite measurement
7
47
292
99.8
arachidonic acid measurement
2
9
10
99.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
43
99.9
docosapentaenoic acid measurement
16
99.8
high density lipoprotein cholesterol measurement
40
1.9
99.8
serum metabolite measurement
292
99.8
arachidonic acid measurement
10
99.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fatty acid desaturase 1
VGNC:50375
451243
Macaque
fatty acid desaturase 1
722343
Mouse
MGI:1923517
76267
Rat
RGD:621678
84575
Dog
fatty acid desaturase 1
VGNC:51870
483793
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fatty acid desaturase 1
Macaque
fatty acid desaturase 1
Mouse
Rat
Dog
fatty acid desaturase 1
Publication Statistics
PubMed Score 667.30
PubMed score by year
PubTator Score 241.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title