FABP4
Fatty acid-binding protein, adipocyte
Protein Summary
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
- ENST00000256104
- ENSP00000256104
- ENSG00000170323
- aP2
- ALBP
- AFABP
- A-FABP
- HEL-S-104
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
PubMedID | 0.85 | ||
small molecule perturbation | 0.85 | ||
biological process | 0.84 | ||
transcription factor perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1086.22 (req: < 5)
Gene RIFs: 199 (req: <= 3)
Antibodies: 754 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1086.22 (req: >= 5)
Gene RIFs: 199 (req: > 3)
Antibodies: 754 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 151
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (151)
Protein-Protein Interactions (195)
GDF5
Novelty: 0.00218118
p_int: 0.999999374
p_ni: 7.5e-8
p_wrong: 5.51e-7
Score: 0.242
Data Source: BioPlex,STRINGDB
OAZ3
Family: Enzyme
Novelty: 0.02374168
p_int: 0.999998713
p_ni: 0.000001242
p_wrong: 4.5e-8
Score: 0.242
Data Source: BioPlex,STRINGDB
ATG101
Novelty: 0.03407206
p_int: 0.795946595
p_ni: 0.000035418
p_wrong: 0.204017988
Data Source: BioPlex
Nearest Tclin Targets
Pathways (11)
Reactome (6)
KEGG (2)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Transcriptional regulation of white adipocyte differentiation | ||||
Reactome | Triglyceride catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Transcriptional regulation of white adipocyte differentiation | ||||
Triglyceride catabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (4)
Components (5)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | fatty acid binding protein 4 | VGNC:6679 | 464255 | |||||
Mouse | MGI:88038 | 11770 | ||||||
Rat | RGD:69309 | 79451 | ||||||
Dog | fatty acid binding protein 4 | 608476 | ||||||
Horse | fatty acid-binding protein, adipocyte | 100057425 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | fatty acid binding protein 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | fatty acid binding protein 4 | |||||
Horse | fatty acid-binding protein, adipocyte | |||||
Publication Statistics
PubMed Score 1086.22
PubMed score by year
PubTator Score 491.83
PubTator score by year
Related Publications
Text Mined References (218)
GeneRif Annotations (199)
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