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Tchem
FABP1
Fatty acid-binding protein, liver

Protein Summary
Description
Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295834
  • ENSP00000295834
  • ENSG00000163586

Symbol
  • FABPL
  • FABPL
  • L-FABP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.83
molecular function
0.81
biological term
0.69
cell type or tissue
0.63
chemical
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.77   (req: < 5)
Gene RIFs: 100   (req: <= 3)
Antibodies: 573   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.77   (req: >= 5)
Gene RIFs: 100   (req: > 3)
Antibodies: 573   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (203)
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
p_int:  0.974403288
p_ni:  0.025596674
p_wrong:  3.8e-8
Score:  0.232
Data Source:  BioPlex,STRINGDB
GNPNAT1
Tbio
Family:  Enzyme
Novelty:  0.01739665
p_int:  0.945013934
p_ni:  0.016225777
p_wrong:  0.038760289
Score:  0.42
Data Source:  BioPlex,STRINGDB
PPARA
Tclin
Family:  NR
Novelty:  0.00017403
Score:  0.988
Data Source:  Reactome,STRINGDB
APOA1
Tbio
Novelty:  0.0001216
Score:  0.977
Data Source:  STRINGDB
FABP4
Tchem
Novelty:  0.00107707
Score:  0.969
Data Source:  STRINGDB
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
Score:  0.962
Data Source:  STRINGDB
SLC27A1
Tchem
Family:  Transporter
Novelty:  0.0065328
Score:  0.961
Data Source:  STRINGDB
HMGCS2
Tbio
Family:  Enzyme
Novelty:  0.0103808
Score:  0.96
Data Source:  STRINGDB
CD36
Tbio
Novelty:  0.00140825
Score:  0.958
Data Source:  STRINGDB
CPT1A
Tchem
Family:  Enzyme
Novelty:  0.00281783
Score:  0.958
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Reactome
Triglyceride catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Triglyceride catabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
2
2
45.2
alkaline phosphatase measurement
2
1
1
8.4
39.6
serum alanine aminotransferase measurement
1
1
0
5.9
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
45.2
alkaline phosphatase measurement
1
8.4
39.6
serum alanine aminotransferase measurement
0
5.9
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fatty acid binding protein 1
VGNC:7696
736471
Mouse
MGI:95479
14080
Rat
RGD:2590
24360
Dog
fatty acid binding protein 1
VGNC:40558
403619
Horse
fatty acid binding protein 1
VGNC:17765
100052746
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fatty acid binding protein 1
Mouse
Rat
Dog
fatty acid binding protein 1
Horse
fatty acid binding protein 1
Publication Statistics
PubMed Score 637.77
PubMed score by year
PubTator Score 334.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title