Tbio FAAP20 Fanconi anemia core complex-associated protein 20

Protein Summary

Description

Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.

Uniprot Accession IDs

• Q6NZ36
• A6PW39
• A6PW40
• A6PW41
• A8MQT6
• F2Z2L4
• Q6ZT64
• Q71M24
• Q96ND7

Gene Name

• FAAP20

Ensembl ID

• ENST00000378543
• ENSP00000367804
• ENSG00000162585
• ENST00000378546
• ENSP00000367808
• ENST00000400918
• ENSP00000383709
• ENST00000414253
• ENSP00000410450

Symbol

• C1orf86
• FP7162
• C1orf86

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.03   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 52   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.03   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0