FAAP100
Fanconi anemia core complex-associated protein 100
Protein Summary
Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. FAAP100 is a component of the Fanconi anemia (FA; MIM 277650) core complex and is required for core complex stability and FANCD2 (see MIM 227646) monoubiquitination (Ling et al., 2007 [PubMed 17396147]).[supplied by OMIM, Mar 2008]
- ENST00000327787
- ENSP00000333283
- ENSG00000185504
- C17orf70
- C17orf70
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.5 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 61 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.5 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 61 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (89)
SGF29
Family: Epigenetic
Novelty: 0.0426456
p_int: 0.999964802
p_ni: 0.000035189
p_wrong: 8e-9
Score: 0.218
Data Source: BioPlex,STRINGDB
STX5
Novelty: 0.00964918
p_int: 0.999582396
p_ni: 0.000417604
Score: 0.515
Data Source: BioPlex,STRINGDB
SNX21
Novelty: 0.32916633
p_int: 0.999524116
p_ni: 0.000475882
p_wrong: 3e-9
Data Source: BioPlex
RPL22L1
Novelty: 0.19211417
p_int: 0.99894341
p_ni: 0.00105659
Score: 0.201
Data Source: BioPlex,STRINGDB
GGA1
Novelty: 0.00866392
p_int: 0.998787706
p_ni: 0.001212072
p_wrong: 2.22e-7
Data Source: BioPlex
RASSF8
Novelty: 0.09245647
p_int: 0.998604533
p_ni: 0.001394853
p_wrong: 6.13e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (2)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | DNA Repair | ||||
Reactome | Fanconi Anemia Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
DNA Repair | ||||
Fanconi Anemia Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (1)
Components (4)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (37)
Items per page:
1 – 5 of 37
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 2 | 5 | 5 | 98.2 | |||||
hair color | 2 | 2 | 0 | 1.2 | 94.1 | ||||
refractive error measurement | 2 | 3 | 2 | 5.9 | 84.6 | ||||
Myopia | 2 | 2 | 0 | 3.5 | 82 | ||||
serum alanine aminotransferase measurement | 2 | 1 | 1 | 10.3 | 80.6 | ||||
Items per page:
1 – 5 of 37
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 5 | 98.2 | |||||
hair color | 0 | 1.2 | 94.1 | ||||
refractive error measurement | 2 | 5.9 | 84.6 | ||||
Myopia | 0 | 3.5 | 82 | ||||
serum alanine aminotransferase measurement | 1 | 10.3 | 80.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Fanconi anemia core complex associated protein 100 | VGNC:9426 | 454959 | |||||
Macaque | Fanconi anemia core complex associated protein 100 | 713876 | ||||||
Mouse | MGI:1919135 | 71885 | ||||||
Rat | RGD:1306926 | 303742 | ||||||
Dog | Fanconi anemia core complex associated protein 100 | VGNC:40556 | 608134 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Fanconi anemia core complex associated protein 100 | |||||
Macaque | Fanconi anemia core complex associated protein 100 | |||||
Mouse | ||||||
Rat | ||||||
Dog | Fanconi anemia core complex associated protein 100 | |||||
Publication Statistics
PubMed Score 2.50
PubMed score by year
PubTator Score 1.56
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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