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Tdark
FAAP100
Fanconi anemia core complex-associated protein 100

Protein Summary
Description
Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. FAAP100 is a component of the Fanconi anemia (FA; MIM 277650) core complex and is required for core complex stability and FANCD2 (see MIM 227646) monoubiquitination (Ling et al., 2007 [PubMed 17396147]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327787
  • ENSP00000333283
  • ENSG00000185504

Symbol
  • C17orf70
  • C17orf70
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.5   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.5   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999964802
p_ni:  0.000035189
p_wrong:  8e-9
Score:  0.218
Data Source:  BioPlex,STRINGDB
GPHA2
Tbio
Novelty:  0.01057969
p_int:  0.99996072
p_ni:  0.00003928
Data Source:  BioPlex
STX5
Tbio
Novelty:  0.00964918
p_int:  0.999582396
p_ni:  0.000417604
Score:  0.515
Data Source:  BioPlex,STRINGDB
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.999566256
p_ni:  0.000433744
Data Source:  BioPlex
SNX21
Tdark
Novelty:  0.32916633
p_int:  0.999524116
p_ni:  0.000475882
p_wrong:  3e-9
Data Source:  BioPlex
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.999473096
p_ni:  0.000526904
Data Source:  BioPlex
TSKS
Tbio
Family:  Enzyme
Novelty:  0.0886446
p_int:  0.999449203
p_ni:  0.000550797
Data Source:  BioPlex
RPL22L1
Tdark
Novelty:  0.19211417
p_int:  0.99894341
p_ni:  0.00105659
Score:  0.201
Data Source:  BioPlex,STRINGDB
GGA1
Tbio
Novelty:  0.00866392
p_int:  0.998787706
p_ni:  0.001212072
p_wrong:  2.22e-7
Data Source:  BioPlex
RASSF8
Tbio
Novelty:  0.09245647
p_int:  0.998604533
p_ni:  0.001394853
p_wrong:  6.13e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
DNA Repair (R-HSA-73894)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
5
5
98.2
hair color
2
2
0
1.2
94.1
refractive error measurement
2
3
2
5.9
84.6
Myopia
2
2
0
3.5
82
serum alanine aminotransferase measurement
2
1
1
10.3
80.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
98.2
hair color
0
1.2
94.1
refractive error measurement
2
5.9
84.6
Myopia
0
3.5
82
serum alanine aminotransferase measurement
1
10.3
80.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia core complex associated protein 100
VGNC:9426
454959
Macaque
Fanconi anemia core complex associated protein 100
713876
Mouse
MGI:1919135
71885
Rat
RGD:1306926
303742
Dog
Fanconi anemia core complex associated protein 100
VGNC:40556
608134
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia core complex associated protein 100
Macaque
Fanconi anemia core complex associated protein 100
Mouse
Rat
Dog
Fanconi anemia core complex associated protein 100
Publication Statistics
PubMed Score 2.50
PubMed score by year
PubTator Score 1.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title