FA2H
Fatty acid 2-hydroxylase
Protein Summary
Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:17355976, PubMed:22517924, PubMed:15863841, PubMed:15337768). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (PubMed:17355976). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (By similarity). Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity). This gene encodes a protein that catalyzes the synthesis of 2-hydroxysphingolipids, ...more
- ENST00000219368
- ENSP00000219368
- ENSG00000103089
- FAAH
- FAAH
- FAH1
- SCS7
- SPG35
- FAXDC1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.88 | ||
virus perturbation | 0.76 | ||
histone modification site profile | 0.67 | ||
cellular component | 0.62 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 228.1 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 186 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 228.1 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 186 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (197)
Nearest Tclin Targets
Pathways (11)
Reactome (4)
PathwayCommons (1)
UniProt (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Sphingolipid de novo biosynthesis | ||||
Reactome | Sphingolipid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of lipids | ||||
Sphingolipid de novo biosynthesis | ||||
Sphingolipid metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (4)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.3 | 52.7 | |||||
1 | 1 | 0 | 1.1 | 52.7 | |||||
2 | 1 | 0 | 1.2 | 52 | |||||
telomere length | 1 | 1 | 1 | 15.8 | |||||
body height | 1 | 1 | 1 | 15.8 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 52.7 | |||||
0 | 1.1 | 52.7 | |||||
0 | 1.2 | 52 | |||||
telomere length | 1 | 15.8 | |||||
body height | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | fatty acid 2-hydroxylase | VGNC:13706 | 454243 | |||||
Macaque | fatty acid 2-hydroxylase | 710403 | ||||||
Mouse | MGI:2443327 | 338521 | ||||||
Rat | RGD:1310347 | 307855 | ||||||
Dog | fatty acid 2-hydroxylase | VGNC:40555 | 610417 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | fatty acid 2-hydroxylase | |||||
Macaque | fatty acid 2-hydroxylase | |||||
Mouse | ||||||
Rat | ||||||
Dog | fatty acid 2-hydroxylase | |||||
Publication Statistics
PubMed Score 228.10
PubMed score by year
PubTator Score 41.54
PubTator score by year
Related Publications
Text Mined References (28)
GeneRif Annotations (18)
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0 of 0
PMID | Year | Title |
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