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Tbio
FA2H
Fatty acid 2-hydroxylase

Protein Summary
Description
Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:17355976, PubMed:22517924, PubMed:15863841, PubMed:15337768). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (PubMed:17355976). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (By similarity). Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity). This gene encodes a protein that catalyzes the synthesis of 2-hydroxysphingolipids, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219368
  • ENSP00000219368
  • ENSG00000103089

Symbol
  • FAAH
  • FAAH
  • FAH1
  • SCS7
  • SPG35
  • FAXDC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.88
virus perturbation
0.76
histone modification site profile
0.67
cellular component
0.62
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.1   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.1   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (197)
AGMO
Tbio
Family:  Enzyme
Novelty:  0.03595131
Score:  0.929
Data Source:  STRINGDB
SCD
Tchem
Family:  Enzyme
Novelty:  0.00063325
Score:  0.799
Data Source:  STRINGDB
DCAF17
Tbio
Novelty:  0.04261326
Score:  0.777
Data Source:  STRINGDB
C19orf12
Tbio
Novelty:  0.02182564
Score:  0.766
Data Source:  STRINGDB
DYNC1LI2
Tbio
Novelty:  0.17381295
Score:  0.759
Data Source:  STRINGDB
CYB5R4
Tbio
Family:  Enzyme
Novelty:  0.06424571
Score:  0.739
Data Source:  STRINGDB
PANK2
Tbio
Family:  Kinase
Novelty:  0.00465551
Score:  0.73
Data Source:  STRINGDB
PLA2G6
Tchem
Family:  Enzyme
Novelty:  0.00262569
Score:  0.714
Data Source:  STRINGDB
SCD5
Tchem
Family:  Enzyme
Novelty:  0.00337317
Score:  0.709
Data Source:  STRINGDB
KDSR
Tbio
Family:  Enzyme
Novelty:  0.0408411
Score:  0.705
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
52.7
1
1
0
1.1
52.7
2
1
0
1.2
52
telomere length
1
1
1
15.8
body height
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
52.7
0
1.1
52.7
0
1.2
52
telomere length
1
15.8
body height
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fatty acid 2-hydroxylase
VGNC:13706
454243
Macaque
fatty acid 2-hydroxylase
710403
Mouse
MGI:2443327
338521
Rat
RGD:1310347
307855
Dog
fatty acid 2-hydroxylase
VGNC:40555
610417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fatty acid 2-hydroxylase
Macaque
fatty acid 2-hydroxylase
Mouse
Rat
Dog
fatty acid 2-hydroxylase
Publication Statistics
PubMed Score 228.10
PubMed score by year
PubTator Score 41.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title