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Tchem
F9
Coagulation factor IX

Protein Summary
Description
Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218099
  • ENSP00000218099
  • ENSG00000101981
  • ENST00000394090
  • ENSP00000377650

Symbol
  • FIX
  • P19
  • PTC
  • HEMB
  • THPH8
  • F9 p22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.74
kinase perturbation
0.71
cell type or tissue
0.66
cellular component
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3245.96   (req: < 5)
Gene RIFs: 152   (req: <= 3)
Antibodies: 707   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3245.96   (req: >= 5)
Gene RIFs: 152   (req: > 3)
Antibodies: 707   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 499
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0