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Tbio
INS-IGF2
Insulin, isoform 2

Protein Summary
Description
This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5' region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356578
  • ENSP00000348986
  • ENSG00000129965
  • ENST00000397270
  • ENSP00000380440

Symbol
  • INSIGF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.63
cell line
0.57
phenotype
0.46
trait
0.46
small molecule perturbation
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.33   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.33   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
INSR
Tclin
Family:  Kinase
Novelty:  0.00230617
Score:  0.932
Data Source:  STRINGDB
IDE
Tchem
Family:  Enzyme
Novelty:  0.00207793
Score:  0.872
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.856
Data Source:  STRINGDB
SPN
Tbio
Novelty:  0.00121061
Score:  0.766
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.766
Data Source:  STRINGDB
IGF2
Tbio
Novelty:  0.00021277
Score:  0.707
Data Source:  STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.7
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.668
Data Source:  STRINGDB
ADIPOQ
Tbio
Novelty:  0.00011196
Score:  0.655
Data Source:  STRINGDB
IGF1R
Tclin
Family:  Kinase
Novelty:  0.00034532
Score:  0.616
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (258)
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Items per page:
1 – 5 of 258
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
AMP-activated Protein Kinase (AMPK) Signaling
WikiPathways
AMP-activated Protein Kinase (AMPK) Signaling
WikiPathways
AMP-activated Protein Kinase (AMPK) Signaling
WikiPathways
AMP-activated Protein Kinase (AMPK) Signaling
WikiPathways
AMP-activated Protein Kinase (AMPK) Signaling
Name
Explore in Pharos
Explore in Source
AMP-activated Protein Kinase (AMPK) Signaling
AMP-activated Protein Kinase (AMPK) Signaling
AMP-activated Protein Kinase (AMPK) Signaling
AMP-activated Protein Kinase (AMPK) Signaling
AMP-activated Protein Kinase (AMPK) Signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
8
8
99.2
6
7
3
1.6
99.2
12
12
2
1.2
99.1
6
4
0
1.2
94.1
glomerular filtration rate
5
6
6
7
91.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
8
99.2
3
1.6
99.2
2
1.2
99.1
0
1.2
94.1
glomerular filtration rate
6
7
91.9
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 12.33
PubMed score by year
PubTator Score 16.75
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title