Protein Summary
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]
- ENST00000367797
- ENSP00000356771
- ENSG00000198734
- FVL
- PCCF
- THPH2
- RPRGL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
disease | 0.8 | ||
cellular component | 0.79 | ||
phenotype | 0.76 | ||
tissue | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 597.25 (req: < 5)
Gene RIFs: 568 (req: <= 3)
Antibodies: 361 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 597.25 (req: >= 5)
Gene RIFs: 568 (req: > 3)
Antibodies: 361 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (269)
MMRN1
Novelty: 0.03378128
p_int: 0.999999906
p_ni: 9.1e-8
p_wrong: 3e-9
Score: 0.968
Data Source: BioPlex,STRINGDB
OLR1
Novelty: 0.00123609
p_int: 0.999992129
p_ni: 0.00000787
p_wrong: 1e-9
Score: 0.685
Data Source: BioPlex,STRINGDB
KLRG2
Novelty: 1.19446694
p_int: 0.999939008
p_ni: 0.000026842
p_wrong: 0.00003415
Score: 0.185
Data Source: BioPlex,STRINGDB
TNFSF8
Novelty: 0.01292216
p_int: 0.999931114
p_ni: 0.000051939
p_wrong: 0.000016947
Score: 0.229
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (20)
Reactome (17)
KEGG (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPII-mediated vesicle transport | ||||
Reactome | Cargo concentration in the ER | ||||
Reactome | Common Pathway of Fibrin Clot Formation | ||||
Reactome | ER to Golgi Anterograde Transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
COPII-mediated vesicle transport | ||||
Cargo concentration in the ER | ||||
Common Pathway of Fibrin Clot Formation | ||||
ER to Golgi Anterograde Transport | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (1)
Components (10)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
8 | 4 | 1 | 2.5 | 98.8 | |||||
adhesion molecule measurement | 1 | 2 | 0 | 14.9 | 93.7 | ||||
prothrombin time measurement | 1 | 1 | 1 | 86.9 | |||||
partial thromboplastin time | 1 | 1 | 1 | 82.2 | |||||
ferritin measurement | 1 | 1 | 1 | 81.7 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 2.5 | 98.8 | |||||
adhesion molecule measurement | 0 | 14.9 | 93.7 | ||||
prothrombin time measurement | 1 | 86.9 | |||||
partial thromboplastin time | 1 | 82.2 | |||||
ferritin measurement | 1 | 81.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | coagulation factor V | VGNC:10619 | 457500 | |||||
Mouse | MGI:88382 | 14067 | ||||||
Rat | RGD:1589758 | 304929 | ||||||
Dog | coagulation factor V | VGNC:40551 | 100685858 | |||||
Cow | coagulation factor V | VGNC:28688 | 280687 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | coagulation factor V | |||||
Mouse | ||||||
Rat | ||||||
Dog | coagulation factor V | |||||
Cow | coagulation factor V | |||||
Publication Statistics
PubMed Score 597.25
PubMed score by year
PubTator Score 2870.67
PubTator score by year
Related Publications
Text Mined References (1258)
GeneRif Annotations (568)
Items per page:
0 of 0
PMID | Year | Title |
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