Protein Summary
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the co ...more
- ENST00000334047
- ENSP00000334145
- ENSG00000117525
- ENST00000370207
- ENSP00000359226
- TF
- TFA
- CD142
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
small molecule perturbation | 0.94 | ||
chemical | 0.89 | ||
biological process | 0.82 | ||
biological term | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14676.23 (req: < 5)
Gene RIFs: 530 (req: <= 3)
Antibodies: 863 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14676.23 (req: >= 5)
Gene RIFs: 530 (req: > 3)
Antibodies: 863 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 131
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (131)
Protein-Protein Interactions (175)
TM9SF4
Novelty: 0.10441964
p_int: 0.828121708
p_ni: 0.171878292
Score: 0.513
Data Source: BioPlex,STRINGDB
DAD1
Family: Enzyme
Novelty: 0.00653242
p_int: 0.754089883
p_ni: 0.245909982
p_wrong: 1.35e-7
Score: 0.269
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (3)
KEGG (2)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Extrinsic Pathway of Fibrin Clot Formation | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Extrinsic Pathway of Fibrin Clot Formation | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (2)
Components (7)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
tissue factor measurement | 1 | 3 | 3 | 90.4 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
tissue factor measurement | 3 | 90.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | coagulation factor III, tissue factor | VGNC:9992 | 457038 | |||||
Mouse | MGI:88381 | 14066 | ||||||
Rat | RGD:2587 | 25584 | ||||||
Dog | coagulation factor III, tissue factor | VGNC:54021 | 490153 | |||||
Horse | coagulation factor III, tissue factor | VGNC:50832 | 100058506 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | coagulation factor III, tissue factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | coagulation factor III, tissue factor | |||||
Horse | coagulation factor III, tissue factor | |||||
Publication Statistics
PubMed Score 14676.23
PubMed score by year
PubTator Score 2592.61
PubTator score by year
Related Publications
Text Mined References (587)
GeneRif Annotations (530)
Items per page:
0 of 0
PMID | Year | Title |
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