Tclin F2R Proteinase-activated receptor 1

Protein Summary

Description

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• P25116
• Q53XV0
• Q96RF7
• Q9BUN4
• PAR-1

Gene Name

• F2R

Ensembl ID

• ENST00000319211
• ENSP00000321326
• ENSG00000181104

Symbol

• CF2R
• PAR1
• TR
• TR
• HTR
• CF2R
• PAR1
• PAR-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
PubMedID	0.92
transcription factor perturbation	0.91
histone modification site profile	0.79
small molecule perturbation	0.78

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Proteinase-activated Receptor / Proteinase-activated Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1458.02   (req: < 5)

Gene RIFs: 329   (req: <= 3)

Antibodies: 602   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1458.02   (req: >= 5)

Gene RIFs: 329   (req: > 3)

Antibodies: 602   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 362

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1