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Tclin
F2R
Proteinase-activated receptor 1

Protein Summary
Description
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319211
  • ENSP00000321326
  • ENSG00000181104

Symbol
  • CF2R
  • PAR1
  • TR
  • TR
  • HTR
  • CF2R
  • PAR1
  • PAR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.92
transcription factor perturbation
0.91
histone modification site profile
0.79
small molecule perturbation
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1365.9   (req: < 5)
Gene RIFs: 305   (req: <= 3)
Antibodies: 602   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1365.9   (req: >= 5)
Gene RIFs: 305   (req: > 3)
Antibodies: 602   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 362
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (301)
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.999513499
p_ni:  0.000472542
p_wrong:  0.000013959
Score:  0.916
Data Source:  BioPlex,STRINGDB
CRYL1
Tbio
Family:  Enzyme
Novelty:  0.04513297
p_int:  0.999513499
p_ni:  0.000472542
p_wrong:  0.000013959
Data Source:  BioPlex
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.998
Data Source:  Reactome,STRINGDB
PROCR
Tbio
Novelty:  0.00197724
Score:  0.99
Data Source:  Reactome,STRINGDB
SNX1
Tbio
Novelty:  0.01267973
Score:  0.974
Data Source:  STRINGDB
GNA13
Tbio
Novelty:  0.04149138
Score:  0.956
Data Source:  Reactome,STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.952
Data Source:  Reactome,STRINGDB
GNA15
Tbio
Novelty:  0.00159196
Score:  0.949
Data Source:  Reactome,STRINGDB
GNA12
Tbio
Novelty:  0.06310884
Score:  0.947
Data Source:  Reactome,STRINGDB
F2RL2
Tbio
Family:  GPCR
Novelty:  0.2305357
Score:  0.947
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Common Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
G alpha (q) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (62)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
6
8
99.3
platelet count
3
4
4
6.1
97.9
reticulocyte count
4
4
8
95.8
reticulocyte measurement
2
3
6
94.7
proteinase-activated receptor 1 measurement
1
2
2
82.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
8
99.3
platelet count
4
6.1
97.9
reticulocyte count
8
95.8
reticulocyte measurement
6
94.7
proteinase-activated receptor 1 measurement
2
82.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coagulation factor II thrombin receptor
VGNC:6869
471510
Mouse
MGI:101802
14062
Rat
RGD:2586
25439
Dog
coagulation factor II thrombin receptor
VGNC:40548
488942
Horse
coagulation factor II thrombin receptor
VGNC:17758
100073278
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coagulation factor II thrombin receptor
Mouse
Rat
Dog
coagulation factor II thrombin receptor
Horse
coagulation factor II thrombin receptor
Publication Statistics
PubMed Score 1365.90
PubMed score by year
PubTator Score 745.98
PubTator score by year
Patents
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Related Publications
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PMID
Year
Title