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Tclin
F2R
Proteinase-activated receptor 1

Protein Summary
Description
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319211
  • ENSP00000321326
  • ENSG00000181104

Symbol
  • CF2R
  • PAR1
  • TR
  • TR
  • HTR
  • CF2R
  • PAR1
  • PAR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.92
transcription factor perturbation
0.91
histone modification site profile
0.79
small molecule perturbation
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1458.02   (req: < 5)
Gene RIFs: 305   (req: <= 3)
Antibodies: 602   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1458.02   (req: >= 5)
Gene RIFs: 305   (req: > 3)
Antibodies: 602   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 362
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1