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Tclin
F2
Prothrombin

Protein Summary
Description
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311907
  • ENSP00000308541
  • ENSG00000180210

Symbol
  • PT
  • THPH1
  • RPRGL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
drug
1
protein domain
1
biological process
0.99
chemical
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19887.5   (req: < 5)
Gene RIFs: 705   (req: <= 3)
Antibodies: 1010   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19887.5   (req: >= 5)
Gene RIFs: 705   (req: > 3)
Antibodies: 1010   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2963
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 15
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (2963)
CHEMBL4476621
Rendered image for CHEMBL4476621
CHEMBL4642845
Rendered image for CHEMBL4642845
CHEMBL4647925
Rendered image for CHEMBL4647925
CHEMBL4643449
Rendered image for CHEMBL4643449
CHEMBL4635912
Rendered image for CHEMBL4635912
CHEMBL96433
Rendered image for CHEMBL96433
CHEMBL4517343
Rendered image for CHEMBL4517343
Peptide boronate
Rendered image for Peptide boronate
Peptide boronate
Rendered image for Peptide boronate
Protein-Protein Interactions (515)
FGA
Tbio
Novelty:  0.00107227
Score:  0.999
Data Source:  Reactome,STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
Score:  0.999
Data Source:  Reactome,STRINGDB
FGG
Tbio
Novelty:  0.00404457
Score:  0.998
Data Source:  Reactome,STRINGDB
SERPIND1
Tbio
Novelty:  0.00120897
Score:  0.998
Data Source:  Reactome,STRINGDB
THBD
Tbio
Novelty:  0.00039359
Score:  0.998
Data Source:  Reactome,STRINGDB
F2R
Tclin
Family:  GPCR
Novelty:  0.00080964
Score:  0.998
Data Source:  Reactome,STRINGDB
F5
Tbio
Novelty:  0.00161772
Score:  0.998
Data Source:  Reactome,STRINGDB
FGB
Tbio
Novelty:  0.00437751
Score:  0.997
Data Source:  Reactome,STRINGDB
PROC
Tchem
Family:  Enzyme
Novelty:  0.00440723
Score:  0.996
Data Source:  Reactome,STRINGDB
SERPINA5
Tbio
Family:  Enzyme
Novelty:  0.00152504
Score:  0.994
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (58)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Complement cascade
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Class A/1 (Rhodopsin-like receptors)
Common Pathway of Fibrin Clot Formation
Complement cascade
Formation of Fibrin Clot (Clotting Cascade)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (51)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
2
1
1.9
93.6
high density lipoprotein cholesterol measurement
3
3
4
92.2
bone density
3
5
5
84.4
femoral neck bone mineral density
2
2
2
74.7
heel bone mineral density
1
1
1
72.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.9
93.6
high density lipoprotein cholesterol measurement
4
92.2
bone density
5
84.4
femoral neck bone mineral density
2
74.7
heel bone mineral density
1
72.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coagulation factor II, thrombin
VGNC:7501
451158
Macaque
coagulation factor II, thrombin
712729
Mouse
MGI:88380
14061
Rat
RGD:61996
29251
Dog
coagulation factor II, thrombin
VGNC:40547
100856539
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coagulation factor II, thrombin
Macaque
coagulation factor II, thrombin
Mouse
Rat
Dog
coagulation factor II, thrombin
Publication Statistics
PubMed Score 19887.50
PubMed score by year
PubTator Score 18265.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title