Protein Summary
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
- ENST00000311907
- ENSP00000308541
- ENSG00000180210
- PT
- THPH1
- RPRGL2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
drug | 1 | ||
protein domain | 1 | ||
biological process | 0.99 | ||
chemical | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23197.95 (req: < 5)
Gene RIFs: 775 (req: <= 3)
Antibodies: 1010 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23197.95 (req: >= 5)
Gene RIFs: 775 (req: > 3)
Antibodies: 1010 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 44
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2977
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 15