Protein Summary
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
- ENST00000311907
- ENSP00000308541
- ENSG00000180210
- PT
- THPH1
- RPRGL2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
drug | 1 | ||
protein domain | 1 | ||
biological process | 0.99 | ||
chemical | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19887.5 (req: < 5)
Gene RIFs: 705 (req: <= 3)
Antibodies: 1010 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19887.5 (req: >= 5)
Gene RIFs: 705 (req: > 3)
Antibodies: 1010 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 44
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2963
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 15
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (15)
Active Ligands (2963)
Protein-Protein Interactions (515)
Nearest Tclin Targets
Pathways (58)
Reactome (27)
KEGG (6)
PathwayCommons (8)
WikiPathways (17)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Common Pathway of Fibrin Clot Formation | ||||
Reactome | Complement cascade | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
Common Pathway of Fibrin Clot Formation | ||||
Complement cascade | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
Viral Interactions (0)
Gene Ontology Terms (51)
Functions (8)
Components (7)
Processes (36)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
5 | 2 | 1 | 1.9 | 93.6 | |||||
high density lipoprotein cholesterol measurement | 3 | 3 | 4 | 92.2 | |||||
bone density | 3 | 5 | 5 | 84.4 | |||||
femoral neck bone mineral density | 2 | 2 | 2 | 74.7 | |||||
heel bone mineral density | 1 | 1 | 1 | 72.5 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.9 | 93.6 | |||||
high density lipoprotein cholesterol measurement | 4 | 92.2 | |||||
bone density | 5 | 84.4 | |||||
femoral neck bone mineral density | 2 | 74.7 | |||||
heel bone mineral density | 1 | 72.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | coagulation factor II, thrombin | VGNC:7501 | 451158 | |||||
Macaque | coagulation factor II, thrombin | 712729 | ||||||
Mouse | MGI:88380 | 14061 | ||||||
Rat | RGD:61996 | 29251 | ||||||
Dog | coagulation factor II, thrombin | VGNC:40547 | 100856539 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | coagulation factor II, thrombin | |||||
Macaque | coagulation factor II, thrombin | |||||
Mouse | ||||||
Rat | ||||||
Dog | coagulation factor II, thrombin | |||||
Publication Statistics
PubMed Score 19887.50
PubMed score by year
PubTator Score 18265.41
PubTator score by year
Related Publications
Text Mined References (1365)
GeneRif Annotations (705)
Items per page:
0 of 0
PMID | Year | Title |
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